5-HT Drives Mortality in Sepsis Induced by Cecal Ligation and Puncture in Mice

Figure 8

Lack of 5-HT alleviates the histopathology damage and organ dysfunction in the heart in CLP-induced sepsis in mice. The animal heart tissues were harvested at 6 h or 24 h after CLP administration. H&E staining was conducted as described above. In the heart, the KO-CLP mice showed less inflammatory cell infiltration, necrosis, and degeneration than the WT-CLP mice. The ejection fraction was measured as an assessment of heart dysfunction (, ejection fraction: mean ± SD; there has no significant difference at both 6 h and 24 h after the CLP administration).