5-HT Drives Mortality in Sepsis Induced by Cecal Ligation and Puncture in Mice

Figure 9

Lack of 5-HT decreases the level of serum cytokines in CLP-induced sepsis. The levels of serum TNF-α and IL-6 were measured with commercial ELISA kits according to the instructions of the manufacturer. A lack of 5-HT reduced the serum TNF-α and IL-6 concentrations (, mean ± SD, TNF-α: versus the WT-CLP group at 6 h after the CLP administration. versus the WT-CLP group at 24 h after the CLP administration; IL-6: versus the WT-CLP group at 24 h after the CLP administration).