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Mediators of Inflammation
Volume 2017, Article ID 6374283, 12 pages
https://doi.org/10.1155/2017/6374283
Research Article

5-HT Drives Mortality in Sepsis Induced by Cecal Ligation and Puncture in Mice

1Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China
2Department of Surgical Intensive Care Unit, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China
3Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China

Correspondence should be addressed to Chang Liu; moc.361@rotcodgnahcuil

Received 21 January 2017; Accepted 30 April 2017; Published 13 June 2017

Academic Editor: Ulrich Eisel

Copyright © 2017 Jingyao Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Singer, C. S. Deutschman, C. W. Seymour et al., “The third international consensus definitions for sepsis and septic shock (sepsis-3),” Jama, vol. 315, no. 8, pp. 801–810, 2016. View at Publisher · View at Google Scholar · View at Scopus
  2. C. W. Seymour, V. X. Liu, T. J. Iwashyna et al., “Assessment of clinical criteria for sepsis: for the third International consensus definitions for sepsis and septic shock (sepsis-3),” Jama, vol. 315, no. 8, pp. 762–774, 2016. View at Publisher · View at Google Scholar · View at Scopus
  3. A. Rhodes, L. E. Evans, W. Alhazzani et al., “Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016,” Intensive Care Medicine, vol. 43, no. 3, pp. 304–377, 2017. View at Publisher · View at Google Scholar
  4. J. Rossaint and A. Zarbock, “Pathogenesis of multiple organ failure in sepsis,” Critical Reviews in Immunology, vol. 35, no. 4, pp. 277–291, 2015. View at Google Scholar
  5. G. Sganga, “Surgical sepsis,” Urologia, vol. 82, no. 2, pp. 75–83, 2015. View at Publisher · View at Google Scholar
  6. G. Lamprecht and A. Heininger, “Current aspects of sepsis caused by bacterial translocation,” Zentralblatt für Chirurgie, vol. 137, no. 3, pp. 274–278, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. E. A. Deitch, “Gut-origin sepsis: evolution of a concept,” The Surgeon, vol. 10, no. 6, pp. 350–6, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. I. M. Cojocaru, C. Musuroi, S. Iacob, and M. Cojocaru, “Investigation of TNF-alpha, IL-6, IL-8 and of procalcitonin in patients with neurologic complications in sepsis,” Romanian Journal of Internal Medicine, vol. 41, no. 1, pp. 83–93, 2003. View at Google Scholar
  9. O. Erbas and D. Taskiran, “Sepsis-induced changes in behavioral stereotypy in rats; involvement of tumor necrosis factor-alpha, oxidative stress, and dopamine turnover,” The Journal of Surgical Research, vol. 186, no. 1, pp. 262–268, 2014. View at Publisher · View at Google Scholar · View at Scopus
  10. C. Quoilin, A. Mouithys-Mickalad, S. Lecart, M. P. Fontaine-Aupart, and M. Hoebeke, “Evidence of oxidative stress and mitochondrial respiratory chain dysfunction in an in vitro model of sepsis-induced kidney injury,” Biochimica et Biophysica Acta, vol. 1837, no. 10, pp. 1790–1800, 2014. View at Publisher · View at Google Scholar · View at Scopus
  11. A. N. Aksoy, A. Toker, M. Celik, M. Aksoy, Z. Halıcı, and H. Aksoy, “The effect of progesterone on systemic inflammation and oxidative stress in the rat model of sepsis,” Indian Journal of Pharmacology, vol. 46, no. 6, pp. 622–6, 2014. View at Publisher · View at Google Scholar · View at Scopus
  12. L. F. Mohammad-Zadeh, L. Moses, and S. M. Gwaltney-Brant, “Serotonin: a review,” Journal of Veterinary Pharmacology and Therapeutics, vol. 31, no. 3, pp. 187–199, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. F. Cote, E. Thevenot, C. Fligny et al., “Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function,” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 23, pp. 13525–13530, 2003. View at Publisher · View at Google Scholar · View at Scopus
  14. K. Y. Choi, H. K. Yoon, and Y. K. Kim, “Association between serotonin-related polymorphisms in 5HT2A, TPH1, TPH2 genes and bipolar disorder in Korean population,” Psychiatry Investigation, vol. 7, no. 1, pp. 60–67, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. D. J. Walther, J. U. Peter, S. Bashammakh et al., “Synthesis of serotonin by a second tryptophan hydroxylase isoform,” Science, vol. 299, no. 5603, p. 76, 2003. View at Publisher · View at Google Scholar · View at Scopus
  16. M. S. Shajib and W. I. Khan, “The role of serotonin and its receptors in activation of immune responses and inflammation,” Acta Physiologica (Oxford, England), vol. 213, no. 3, pp. 561–574, 2015. View at Publisher · View at Google Scholar · View at Scopus
  17. B. Olivier, “Serotonin: a never-ending story,” European Journal of Pharmacology, vol. 753, pp. 2–18, 2015. View at Publisher · View at Google Scholar · View at Scopus
  18. J. Namkung, H. Kim, and S. Park, “Peripheral serotonin: a new player in systemic energy homeostasis,” Molecules and Cells, vol. 38, no. 12, pp. 1023–1028, 2015. View at Publisher · View at Google Scholar · View at Scopus
  19. M. de Las Casas-Engel and A. L. Corbi, “Serotonin modulation of macrophage polarization: inflammation and beyond,” Advances in Experimental Medicine and Biology, vol. 824, pp. 89–115, 2014. View at Publisher · View at Google Scholar · View at Scopus
  20. J. Zhang, Q. Pang, S. Song et al., “Role of serotonin in MODS: deficiency of serotonin protects against zymosan-induced multiple organ failure in mice,” Shock, vol. 43, no. 3, pp. 276–284, 2015. View at Publisher · View at Google Scholar · View at Scopus
  21. J. Zhang, S. Song, Q. Pang et al., “Serotonin deficiency exacerbates acetaminophen-induced liver toxicity in mice,” Scientific Reports, vol. 5, p. 8098, 2015. View at Publisher · View at Google Scholar · View at Scopus
  22. J. M. Yano, K. Yu, G. P. Donaldson et al., “Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis,” Cell, vol. 161, no. 2, pp. 264–276, 2015. View at Publisher · View at Google Scholar · View at Scopus
  23. G. M. Mawe and J. M. Hoffman, “Serotonin signalling in the gut—functions, dysfunctions and therapeutic targets,” Nature Reviews. Gastroenterology & Hepatology, vol. 10, no. 8, pp. 473–486, 2013. View at Publisher · View at Google Scholar · View at Scopus
  24. G. W. Hunninghake, K. C. Doerschug, A. B. Nymon, G. A. Schmidt, D. K. Meyerholz, and A. Ashare, “Insulin-like growth factor-1 levels contribute to the development of bacterial translocation in sepsis,” American Journal of Respiratory and Critical Care Medicine, vol. 182, no. 4, pp. 517–525, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. A. Nocito, F. Dahm, W. Jochum et al., “Serotonin mediates oxidative stress and mitochondrial toxicity in a murine model of nonalcoholic steatohepatitis,” Gastroenterology, vol. 133, no. 2, pp. 608–618, 2007. View at Publisher · View at Google Scholar · View at Scopus
  26. D. Duerschmied, G. L. Suidan, M. Demers et al., “Platelet serotonin promotes the recruitment of neutrophils to sites of acute inflammation in mice,” Blood, vol. 121, no. 6, pp. 1008–1015, 2013. View at Publisher · View at Google Scholar · View at Scopus
  27. P. Farand, M. Hamel, F. Lauzier, G. E. Plante, and O. Lesur, “Review article: organ perfusion/permeability-related effects of norepinephrine and vasopressin in sepsis,” Canadian Journal of Anaesthesia, vol. 53, no. 9, pp. 934–946, 2006. View at Publisher · View at Google Scholar · View at Scopus
  28. Y. Li, C. Hadden, A. Cooper et al., “Sepsis-induced elevation in plasma serotonin facilitates endothelial hyperpermeability,” Scientific Reports, vol. 6, p. 22747, 2016. View at Publisher · View at Google Scholar · View at Scopus
  29. P. A. Lang, C. Contaldo, P. Georgiev et al., “Aggravation of viral hepatitis by platelet-derived serotonin,” Nature Medicine, vol. 14, no. 7, pp. 756–761, 2008. View at Publisher · View at Google Scholar · View at Scopus
  30. M. Lesurtel, R. Graf, B. Aleil et al., “Platelet-derived serotonin mediates liver regeneration,” Science, vol. 312, no. 5770, pp. 104–107, 2006. View at Publisher · View at Google Scholar · View at Scopus
  31. G. F. Weber, B. G. Chousterman, S. He et al., “Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis,” Science, vol. 347, no. 6227, pp. 1260–1265, 2015. View at Publisher · View at Google Scholar · View at Scopus
  32. B. Hu, Y. Li, L. Gao et al., “Hepatic induction of fatty acid binding protein 4 plays a pathogenic role in sepsis in mice,” American Journal of Pathology, vol. 187, no. 5, pp. 1059–1067, 2017. View at Publisher · View at Google Scholar
  33. E. Lilley, R. Armstrong, N. Clark et al., “Refinement of animal models of sepsis and septic shock,” Shock, vol. 43, no. 4, pp. 304–316, 2015. View at Publisher · View at Google Scholar · View at Scopus
  34. R. Gennari, J. W. Alexander, and T. Eaves-Pyles, “Effect of different combinations of dietary additives on bacterial translocation and survival in gut-derived sepsis,” JPEN Journal of Parenteral and Enteral Nutrition, vol. 19, no. 4, pp. 319–325, 1995. View at Publisher · View at Google Scholar · View at Scopus
  35. C. Vaishnavi, “Translocation of gut flora and its role in sepsis,” Indian Journal of Medical Microbiology, vol. 31, no. 4, pp. 334–342, 2013. View at Publisher · View at Google Scholar · View at Scopus
  36. H. Tsujimoto, S. Ono, and H. Mochizuki, “Role of translocation of pathogen-associated molecular patterns in sepsis,” Digestive Surgery, vol. 26, no. 2, pp. 100–109, 2009. View at Publisher · View at Google Scholar · View at Scopus
  37. L. C. Denlinger, “Low-dose prostacyclin reverses endotoxin-induced intestinal vasoconstriction: potential for the prevention of bacterial translocation in early sepsis,” Critical Care Medicine, vol. 29, no. 2, pp. 453-454, 2001. View at Publisher · View at Google Scholar
  38. M. Chen, L. Gao, P. Chen et al., “Serotonin-exacerbated DSS-induced colitis is associated with increase in MMP-3 and MMP-9 expression in the mouse colon,” Mediators of Inflammation, vol. 2016, p. 5359768, 2016. View at Publisher · View at Google Scholar · View at Scopus
  39. M. Mauler, C. Bode, and D. Duerschmied, “Platelet serotonin modulates immune functions,” Hämostaseologie, vol. 36, no. 1, pp. 11–16, 2016. View at Publisher · View at Google Scholar · View at Scopus
  40. E. C. Nowak, V. C. de Vries, A. Wasiuk et al., “Tryptophan hydroxylase-1 regulates immune tolerance and inflammation,” The Journal of Experimental Medicine, vol. 209, no. 11, pp. 2127–2135, 2012. View at Publisher · View at Google Scholar · View at Scopus
  41. J. M. Cavaillon, M. Adib-Conquy, C. Fitting, C. Adrie, and D. Payen, “Cytokine cascade in sepsis,” Scandinavian Journal of Infectious Diseases, vol. 35, no. 9, pp. 535–544, 2003. View at Publisher · View at Google Scholar · View at Scopus
  42. W. Ertel, F. Krombach, J. P. Kremer et al., “Mechanisms of cytokine cascade activation in patients with sepsis: normal cytokine transcription despite reduced CD14 receptor expression,” Surgery, vol. 114, no. 2, pp. 243–250, 1993, discussion 250-1. View at Google Scholar
  43. H. K. de Jong, T. van der Poll, and W. J. Wiersinga, “The systemic pro-inflammatory response in sepsis,” Journal of Innate Immunity, vol. 2, no. 5, pp. 422–430, 2010. View at Publisher · View at Google Scholar · View at Scopus
  44. D. A. Lowes, N. R. Webster, M. P. Murphy, and H. F. Galley, “Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis,” British Journal of Anaesthesia, vol. 110, no. 3, pp. 472–480, 2013. View at Publisher · View at Google Scholar · View at Scopus
  45. H. F. Galley, “Oxidative stress and mitochondrial dysfunction in sepsis,” British Journal of Anaesthesia, vol. 107, no. 1, pp. 57–64, 2011. View at Publisher · View at Google Scholar · View at Scopus
  46. C. H. Liu, W. D. Zhang, J. J. Wang, and S. D. Feng, “Senegenin ameliorate acute lung injury through reduction of oxidative stress and inhibition of inflammation in cecal ligation and puncture-induced sepsis rats,” Inflammation, vol. 39, no. 2, pp. 900–906, 2016. View at Publisher · View at Google Scholar · View at Scopus
  47. E. Zolali, P. Asgharian, H. Hamishehkar, M. Kouhsoltani, H. Khodaii, and H. Hamishehkar, “Effects of gamma oryzanol on factors of oxidative stress and sepsis-induced lung injury in experimental animal model,” Iranian Journal of Basic Medical Sciences, vol. 18, no. 12, pp. 1257–1263, 2015. View at Google Scholar
  48. O. J. Cassol-Jr, C. M. Comim, B. R. Silva et al., “Treatment with cannabidiol reverses oxidative stress parameters, cognitive impairment and mortality in rats submitted to sepsis by cecal ligation and puncture,” Brain Research, vol. 1348, pp. 128–138, 2010. View at Publisher · View at Google Scholar · View at Scopus
  49. Y. J. Chen, C. L. Gong, F. Tan, and S. L. Zhou, “Pretreatment with dexmedetomidine ameliorates renal inflammation and oxidative stress in rats with lipopolysaccharide-induced sepsis and acute kidney injury,” Nan Fang Yi Ke da Xue Xue Bao, vol. 35, no. 10, pp. 1472–1475, 2015. View at Google Scholar
  50. F. Gerin, U. Sener, H. Erman et al., “The effects of quercetin on acute lung injury and biomarkers of inflammation and oxidative stress in the rat model of sepsis,” Inflammation, vol. 39, no. 2, pp. 700–705, 2016. View at Publisher · View at Google Scholar · View at Scopus