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Mediators of Inflammation
Volume 2017, Article ID 6386453, 8 pages
https://doi.org/10.1155/2017/6386453
Research Article

Association between Interleukin-10-1082 G/A and Tumor Necrosis Factor- 308 G/A Gene Polymorphisms and Respiratory Distress Syndrome in Iranian Preterm Infants

1Clinical Biochemistry Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
2Department of Pediatrics, Shahrekord University of Medical Sciences, Shahrekord, Iran
3Cellular and Molecular Research Center, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
4Subspecialty of Pediatrics, Department of Pediatrics, Shahrekord University of Medical Sciences, Shahrekord, Iran
5Department of Medical Genetics, Shahrekord University of Medical Sciences, Shahrekord, Iran

Correspondence should be addressed to Abolfazl Khoshdel; ri.ca.smuks@ledhsohk.a

Received 26 October 2016; Revised 2 January 2017; Accepted 18 January 2017; Published 16 February 2017

Academic Editor: Tânia Silvia Fröde

Copyright © 2017 Abolfazl Khoshdel et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Cytokine polymorphisms may contribute to the prevalence of respiratory distress syndrome. The present study was done to investigate the frequency of interleukin- (IL-) 10 and tumor necrosis factor- (TNF-) α gene polymorphisms and their association with the risk of RDS in preterm infants. One-hundred and nineteen patients with RDS and 119 healthy preterm infants were enrolled. PCR restriction fragment length polymorphism was used to determine the frequency of IL-10 and TNF-α genotypes at -1082 A and -308 A, respectively. One-hundred and nineteen out of 238 infants had RDS (50%). The age of the mothers and gestational age ranged 17–45 (mean: ) years and 24–34 (mean: ) weeks, respectively. Totally, 23 deaths were recorded in the RDS group. Incidence of TNF-α-308 A/A and TNF-α-308 G/A was 84% and 16%, respectively. TNF-a-308 G/G was not found in both groups. Prevalence of IL-10-1082 G/G and IL-10-1082 G/A variants was 65.5% and 34.5%, respectively. IL-10-1082 A/A was not found in both groups. The incidence of the allele G in the IL-10-1082 polymorphism was lower in RDS group (). We found that the risk of RDS was correlated to sex, gestational age, and IL-10-1082.