TWEAK/Fn14 Activation Participates in Skin Inflammation

Figure 1

The diagram for TWEAK, Fn14, and relevant cytokines in skin structure. (a) The structures of TWEAK and Fn14 partners. (b) Fn14 is expressed on multiple cell types, including keratinocytes (KC), dermal fibroblasts (F), macrophages (Mϕ), and microvascular endothelial cells (EC). Intracellular TWEAK protein is expressed by monocytes (MO), dendritic cells (DC), and natural killer (NK) cells. TWEAK induces keratinocytes to express proinflammatory cytokines, such as IL-6, IL-8, RANTES, GM-CSF, IP-10, CCL17, and CCL22, which promote the migration of macrophages. TWEAK also induces the production of IL-6, IL-8, RANTES, IP-10, and PGE2 in dermal fibroblasts as well as E-selectin and ICAM-1 in microvascular endothelial cells.

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