Mediators of Inflammation / 2017 / Article / Tab 1

Review Article

TWEAK/Fn14 Activation Participates in Skin Inflammation

Table 1

The action of TWEAK in different skin diseases.

DiseasesEffect on target cells or animal modelsReferences

PsoriasisKC: to enhance chemokine expression and cell proliferation[22, 65]
Murine model: to induce immune cell infiltrates in lesional skin
ADKC: to increase TNF-α expression and induce apoptosis[28, 65]
Dermal fibroblast: to regulate chemokine expression
Murine model: to induce cellular infiltrates, migration of immune cells, and chemokine expression
Cutaneous vasculitisHMEC: to regulate NF-κB activation and chemokine production[71, 92]
Murine model: to induce endothelial damage and perivascular leukocyte infiltrates
HPV infectionKC: to enhance TNFR2 expression and cell proliferation[64]
CarcinogenesisVarious tumor cells: to induce cell proliferation or apoptosis in a cytokine-dependent way[64, 112, 113]
Glioma cells: to promote cell migration and invasion
KC: to induce cell proliferation
Vascular ECs: to upregulate FGF-2 and VEGF-A expression and to promote angiogenesis
Cutaneous lupus erythematosusKC: to enhance Ro52 and proinflammatory cytokine expression and induce apoptosis[70, 109]
Macrophage: to enhance chemoattraction and cytokine expression (including TWEAK)
MRL/lpr mice: to induce chemokine production, cell infiltration, and apoptosis
Systemic sclerosisMonocytes/macrophages: to lead to greater extent of skin fibrosis or to exert as a protective role against fibrosis[111, 114]
Polymyositis & dermatomyositisMyoblast: to induce degradation of myosin heavy chain, to affect cell proliferation and differentiation, and to induce metabolic abnormalities[107, 115, 116]
Murine model: to induce muscle atrophy and interstitial fibrosis
Bullous pemphigoidKC: to reduce BP180 expression and suppresses cell adhesion[8]

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