AM966, an Antagonist of Lysophosphatidic Acid Receptor 1, Increases Lung Microvascular Endothelial Permeability through Activation of Rho Signaling Pathway and Phosphorylation of VE-Cadherin

<div>AM966 reduces pulmonary microvascular cell barrier integrity through LPA1/G<i>α</i>12/13-mediated phosphorylation of MLC and VE-cadherin. AM966 is ligated to LPA1 and triggers RhoA/Rho kinase pathway, thereby increasing MLC phosphorylation and cytoskeletal rearrangement. AM966 induces phosphorylation of VE-cadherin. Therefore, AM966 increases lung endothelial permeability.</div>

Mediators of Inflammation

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Figure 6

Figure 6: AM966, an Antagonist of Lysophosphatidic Acid Receptor 1, Increases Lung Microvascular Endothelial Permeability through Activation of Rho Signaling Pathway and Phosphorylation of VE-Cadherin 

Figure 6 | AM966, an Antagonist of Lysophosphatidic Acid Receptor 1, Increases Lung Microvascular Endothelial Permeability through Activation of Rho Signaling Pathway and Phosphorylation of VE-Cadherin 