T-Cell Subsets in Rheumatoid Arthritis Patients on Long-Term Anti-TNF or IL-6 Receptor Blocker Therapy
Table 3
Subgroup analysis in the long-term-treated RA patient groups according to the length of the biological therapy.
CD4
CD4/CD45RA
CD4/CD45RO
CD4/CD69
CD4/HLADR
CD4/CD25
CD8
CD8/CD45RA
CD8/CD45RO
CD8/HLADR
CD8/CD69
Th1
Th2
Th17
Treg
Anti-TNF responders
“Short”
Median
25.35
4.60a
46.95
1.95
8.03
1.00
9.18
4.68a
5.97
2.90
0.56
18.2
7.51
2.49
4.67
25% percentile
32.47
7.73
60.32
2.74
9.13
1.62
19.45
46.70
18.10
10.51
2.50
23.15
9.02
3.35
6.82
75% percentile
25.35
4.60
46.95
1.95
8.03
1.00
9.18
4.68
5.97
2.90
0.56
18.2
7.51
2.49
4.67
“Mid”
Median
31.25
8.14a
49.25a
1.92
5.58
1.16
13.05
14.11a
15.25
4.01
1.10
20.7
7.76
2.90
5.57
25% percentile
26.65
4.06
45.45
1.32
5.36
0.88
10.29
5.67
12.22
1.84
0.63
18.8
7.17
2.56
4.88
75% percentile
36.77
10.57
66.82
2.69
7.89
1.24
16.07
31.45
17.95
5.96
1.62
23.47
10.05
3.35
6.11
“Long”
Median
22.20
1.79
37.30
0.84
6.02
1.10
8.57
3.97
10.85
6.82
0.78
19.90
8.06
2.38
6.43
25% percentile
16.70
1.28
13.69
0.23
4.35
0.51
4.63
1.08
4.36
3.03
0.49
16.65
6.99
2.17
4.30
75% percentile
32.87
2.91
56.00
2.59
12.57
1.77
17.97
6.32
14.20
9.74
1.09
23.77
9.00
3.04
6.86
Anti-TNF nonresponders
“Short”
Median
41.00
3.49
53.20
1.07
5.89
1.59
9.54
2.08
5.72
5.41
0.61
18.70
7.96
4.93
4.44
25% percentile
30.90
3.24
26.80
1.03
3.78
0.97
7.62
1.55
3.16
2.82
0.58
12.79
7.51
2.85
4.32
75% percentile
41.30
10.99
57.85
3.02
7.25
5.52
18.87
11.69
16.11
9.35
0.62
20.45
11.23
5.12
5.70
“Long”
Median
40.15
4.52
55.70
1.37
4.20
2.32
13.35
7.45
11.19
4.07
1.36
18.25
8.70
2.71
5.86
25% percentile
25.62
2.47
22.92
1.15
2.60
1.16
6.33
2.40
6.86
1.33
1.05
11.92
6.65
1.45
5.45
75% percentile
44.92
13.17
62.67
2.63
6.29
5.65
20.57
36.12
14.87
4.67
2.07
21.52
11.12
4.20
7.81
Anti-IL-6R responders
“Short”
Median
31.70
3.96
28.7
5.19
4.17
4.28
5.79
3.47
8.52
2.88
3.68
4.83
13.00
5.19
4.69
25% percentile
25.30
1.81
17.7
1.85
2.52
1.50
3.73
1.71
7.37
1.46
1.76
3.40
9.31
3.09
4.01
75% percentile
42.40
8.03
42.7
8.10
5.83
4.78
6.96
9.96
15.20
4.23
11.50
13.60
14.30
6.19
5.83
“Mid”
Median
27.05
3.21
47.75
3.63
5.65
4.30
5.41
4.54
9.70
2.92
6.96
7.41
11.21
4.69
4.75
25% percentile
25.77
2.51
6.41
1.35
3.51
1.07
4.04
2.89
8.15
1.60
3.37
3.44
6.74
3.27
4.58
75% percentile
36.25
10.04
64.60
6.4
10.47
6.02
8.82
32.48
12.30
8.22
10.29
17.82
16.40
5.38
5.00
“Long”
Median
41.35
2.89
43.35
4.10
5.38
4.71
5.53
5.83
11.70
2.81
3.99
5.20
11.90
4.96
4.63
25% percentile
34.82
1.21
10.96
2.01
4.48
1.63
4.14
2.52
8.17
2.01
2.82
3.03
9.99
4.41
4.06
75% percentile
49.07
4.86
51.02
9.30
7.39
5.34
7.68
39.12
14.27
4.51
12.35
8.77
13.40
5.43
6.32
Numbers indicate the median percentages and 25% and 75% percentile values within the whole T-cell population (CD4 and CD8 cells), or within CD4 cells (Th1, Th2, Th17, Treg, and ratios), or for the other markers within the CD4 or CD8 cells, as indicated. a versus anti-TNF responders long-term.
