Table 3: Subgroup analysis in the long-term-treated RA patient groups according to the length of the biological therapy.

CD4CD4/CD45RACD4/CD45ROCD4/CD69CD4/HLADRCD4/CD25CD8CD8/CD45RACD8/CD45ROCD8/HLADRCD8/CD69Th1Th2Th17Treg

Anti-TNF responders“Short”Median25.354.60a46.951.958.031.009.184.68a5.972.900.5618.27.512.494.67
25% percentile32.477.7360.322.749.131.6219.4546.7018.1010.512.5023.159.023.356.82
75% percentile25.354.6046.951.958.031.009.184.685.972.900.5618.27.512.494.67
“Mid”Median31.258.14a49.25a1.925.581.1613.0514.11a15.254.011.1020.77.762.905.57
25% percentile26.654.0645.451.325.360.8810.295.6712.221.840.6318.87.172.564.88
75% percentile36.7710.5766.822.697.891.2416.0731.4517.955.961.6223.4710.053.356.11
“Long”Median22.201.7937.300.846.021.108.573.9710.856.820.7819.908.062.386.43
25% percentile16.701.2813.690.234.350.514.631.084.363.030.4916.656.992.174.30
75% percentile32.872.9156.002.5912.571.7717.976.3214.209.741.0923.779.003.046.86

Anti-TNF nonresponders“Short”Median41.003.4953.201.075.891.599.542.085.725.410.6118.707.964.934.44
25% percentile30.903.2426.801.033.780.977.621.553.162.820.5812.797.512.854.32
75% percentile41.3010.9957.853.027.255.5218.8711.6916.119.350.6220.4511.235.125.70
“Long”Median40.154.5255.701.374.202.3213.357.4511.194.071.3618.258.702.715.86
25% percentile25.622.4722.921.152.601.166.332.406.861.331.0511.926.651.455.45
75% percentile44.9213.1762.672.636.295.6520.5736.1214.874.672.0721.5211.124.207.81

Anti-IL-6R responders“Short”Median31.703.9628.75.194.174.285.793.478.522.883.684.8313.005.194.69
25% percentile25.301.8117.71.852.521.503.731.717.371.461.763.409.313.094.01
75% percentile42.408.0342.78.105.834.786.969.9615.204.2311.5013.6014.306.195.83
“Mid”Median27.053.2147.753.635.654.305.414.549.702.926.967.4111.214.694.75
25% percentile25.772.516.411.353.511.074.042.898.151.603.373.446.743.274.58
75% percentile36.2510.0464.606.410.476.028.8232.4812.308.2210.2917.8216.405.385.00
“Long”Median41.352.8943.354.105.384.715.535.8311.702.813.995.2011.904.964.63
25% percentile34.821.2110.962.014.481.634.142.528.172.012.823.039.994.414.06
75% percentile49.074.8651.029.307.395.347.6839.1214.274.5112.358.7713.405.436.32

Numbers indicate the median percentages and 25% and 75% percentile values within the whole T-cell population (CD4 and CD8 cells), or within CD4 cells (Th1, Th2, Th17, Treg, and ratios), or for the other markers within the CD4 or CD8 cells, as indicated. a versus anti-TNF responders long-term.