T-Cell Subsets in Rheumatoid Arthritis Patients on Long-Term Anti-TNF or IL-6 Receptor Blocker Therapy
Table 4
Subgroup analysis of cell prevalences in the long-term-treated RA patient groups according to the number of previous switches of anti-TNF therapies.
CD4
CD4/CD45RA
CD4/CD45RO
CD4/CD69
CD4/HLADR
CD4/CD25
CD8
CD8/CD45RA
CD8/CD45RO
CD8/HLADR
CD8/CD69
Th1
Th2
Th17
Treg
Anti-TNF responders
“Switched”
Median
33.40
14.10
40.30
1.47
5.36
0.96
14.20
20.20
14.10
5.51
0.96
16.70
8.95
2.67
6.84
25% percentile
33.05
8.08
40.10
1.14
4.57
0.69
12.40
12.18
9.26
4.07
0.57
15.95
8.36
2.30
5.51
75% percentile
41.75
18.55
44.80
2.02
5.44
1.21
16.50
25.60
15.25
5.75
1.49
17.55
9.47
2.92
6.87
“Nonswitched”
Median
24.40
3.17
47.30
1.80
7.92
1.20
9.77
5.41
12.60
6.19
0.86
21.70
8.02
2.82
5.85
25% percentile
17.25
1.50
19.65
0.46
4.49
0.58
5.34
2.19
5.60
2.89
0.48
17.20
7.13
2.25
4.44
75% percentile
33.15
7.77
64.80
2.91
9.84
1.57
19.25
15.50
17.20
9.74
2.09
23.85
9.24
3.30
6.63
Anti-TNF nonresponders
“Switched”
Median
30.15
2.77
38.55
1.42
3.59
1.54
24.75
8.55
11.02
2.86
1.85
20.90
8.81
1.40
7.09
25% percentile
19.07
2.11
6.30
1.28
1.85
0.94
11.11
2.22
2.76
0.96
1.31
15.40
8.017
1.11
6.19
75% percentile
41.37
11.25
58.70
2.21
6.38
3.53
27.35
29.35
13.57
4.95
2.53
21.90
10.31
3.48
9.19
“Nonswitched”
Median
41.00
4.92
57.50
1.25
4.33
2.94
9.96
7.18
9.48
4.31
1.05
18.10
7.07
4.11
5.65
25% percentile
29.80
3.49
49.80
1.07
2.69
1.19
6.00
2.17
5.72
1.38
0.53
6.90
6.39
2.08
4.64
75% percentile
45.00
12.90
62.50
2.70
6.08
6.39
17.30
33.80
15.40
5.41
1.49
21.50
12.90
4.40
6.14
Anti-IL-6R responders
“Nonswitched”
Median
41.40
1.88
40.00
5.51
5.35
4.50
6.13
4.96
11.50
2.15
5.09
3.90
12.80
5.20
4.85
25% percentile
31.30
1.34
21.20
3.40
3.43
2.35
4.72
2.39
8.49
1.47
2.96
3.00
9.93
4.38
4.12
75% percentile
52.25
7.79
58.10
12.76
7.62
5.50
7.54
37.95
15.20
3.41
12.70
7.67
14.55
5.815
5.98
Switching once
Median
25.70
5.43
28.70
1.44
5.55
1.50
7.54
3.37
8.20
4.23
2.45
16.00
10.70
3.95
4.69
25% percentile
22.90
1.60
9.04
0.77
3.97
0.66
3.86
1.87
5.97
2.30
0.92
6.12
7.35
3.07
4.39
75% percentile
33.65
10.05
43.45
1.85
7.16
3.94
10.2045
33.90
11.75
5.68
5.24
17.85
12.20
4.89
6.17
Switching twice
Median
35.40
4.12
12.50
4.60
5.83
5.14
6.36
6.64
12.50
4.28
4.11
5.65
13.30
5.41
4.45
25% percentile
26.60
3.02
10.70
3.13
5.77
2.47
4.17
2.47
10.70
2.88
3.12
4.92
7.85
3.73
4.21
75% percentile
48.90
10.60
13.30
10.60
8.88
6.57
9.65
37.70
13.30
9.37
9.97
17.30
15.80
6.45
4.75
Switching three times
Median
34.30
2.58
11.80
5.00a
4.17
4.92
5.35
5.93
10.50
2.29
10.40a
3.00a
12.70
5.07
4.81
25% percentile
27.50
2.38
3.29
4.14
3.11
4.78
5.02
5.63
6.46
1.98
5.04
2.72
12.50
5.01
3.82
75% percentile
42.40
2.89
50.00
15.80
4.68
5.35
5.74
9.96
14.80
3.80
16.30
4.33
13.00
5.30
5.06
Numbers indicate the median percentages and 25% and 75% percentile values within the whole T-cell population (CD4 and CD8 cells) or within CD4 cells (Th1, Th2, Th17, Treg, and ratios), or for the other markers within the CD4 or CD8 cells, as indicated. a versus anti-IL-6R responders, switching once.
