Table 4: Subgroup analysis of cell prevalences in the long-term-treated RA patient groups according to the number of previous switches of anti-TNF therapies.

CD4CD4/CD45RACD4/CD45ROCD4/CD69CD4/HLADRCD4/CD25CD8CD8/CD45RACD8/CD45ROCD8/HLADRCD8/CD69Th1Th2Th17Treg

Anti-TNF responders“Switched”Median33.4014.1040.301.475.360.9614.2020.2014.105.510.9616.708.952.676.84
25% percentile33.058.0840.101.144.570.6912.4012.189.264.070.5715.958.362.305.51
75% percentile41.7518.5544.802.025.441.2116.5025.6015.255.751.4917.559.472.926.87
“Nonswitched”Median24.403.1747.301.807.921.209.775.4112.606.190.8621.708.022.825.85
25% percentile17.251.5019.650.464.490.585.342.195.602.890.4817.207.132.254.44
75% percentile33.157.7764.802.919.841.5719.2515.5017.209.742.0923.859.243.306.63

Anti-TNF nonresponders“Switched”Median30.152.7738.551.423.591.5424.758.5511.022.861.8520.908.811.407.09
25% percentile19.072.116.301.281.850.9411.112.222.760.961.3115.408.0171.116.19
75% percentile41.3711.2558.702.216.383.5327.3529.3513.574.952.5321.9010.313.489.19
“Nonswitched”Median41.004.9257.501.254.332.949.967.189.484.311.0518.107.074.115.65
25% percentile29.803.4949.801.072.691.196.002.175.721.380.536.906.392.084.64
75% percentile45.0012.9062.502.706.086.3917.3033.8015.405.411.4921.5012.904.406.14

Anti-IL-6R responders“Nonswitched”Median41.401.8840.005.515.354.506.134.9611.502.155.093.9012.805.204.85
25% percentile31.301.3421.203.403.432.354.722.398.491.472.963.009.934.384.12
75% percentile52.257.7958.1012.767.625.507.5437.9515.203.4112.707.6714.555.8155.98
Switching onceMedian25.705.4328.701.445.551.507.543.378.204.232.4516.0010.703.954.69
25% percentile22.901.609.040.773.970.663.861.875.972.300.926.127.353.074.39
75% percentile33.6510.0543.451.857.163.9410.204533.9011.755.685.2417.8512.204.896.17
Switching twiceMedian35.404.1212.504.605.835.146.366.6412.504.284.115.6513.305.414.45
25% percentile26.603.0210.703.135.772.474.172.4710.702.883.124.927.853.734.21
75% percentile48.9010.6013.3010.608.886.579.6537.7013.309.379.9717.3015.806.454.75
Switching three timesMedian34.302.5811.805.00a4.174.925.355.9310.502.2910.40a3.00a12.705.074.81
25% percentile27.502.383.294.143.114.785.025.636.461.985.042.7212.505.013.82
75% percentile42.402.8950.0015.804.685.355.749.9614.803.8016.304.3313.005.305.06

Numbers indicate the median percentages and 25% and 75% percentile values within the whole T-cell population (CD4 and CD8 cells) or within CD4 cells (Th1, Th2, Th17, Treg, and ratios), or for the other markers within the CD4 or CD8 cells, as indicated. a versus anti-IL-6R responders, switching once.