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Mediators of Inflammation
Volume 2017, Article ID 6904634, 12 pages
Research Article

New Hydroxycinnamic Acid Esters as Novel 5-Lipoxygenase Inhibitors That Affect Leukotriene Biosynthesis

Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB, Canada E1A 3E9

Correspondence should be addressed to Mohamed Touaibia; ac.notcnomu@aibiauot.demahom

Received 24 January 2017; Revised 3 May 2017; Accepted 8 May 2017; Published 7 June 2017

Academic Editor: Sandra Helena Penha Oliveira

Copyright © 2017 Luc H. Boudreau et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Figure S1: Annexin V labelling was performed on PMNL following 20 min incubation at 37°C in the presence of diluent (control, DMSO 0.5%) or compound 13 that showed the best inhibition of 5-LO product biosynthesis. A positive control with 10% EtOH is shown to validate the assay.

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