Mediators of Inflammation / 2017 / Article / Tab 5

Research Article

Associations of Functional MicroRNA Binding Site Polymorphisms in IL23/Th17 Inflammatory Pathway Genes with Gastric Cancer Risk

Table 5

Stratification analysis of the four miRNA binding site SNPs and GC susceptibility.

Variablesrs3748067rs10889677rs1468488rs887796
OR (95% CI)aaOR (95% CI)aaOR (95% CI)aaOR (95% CI)aa

Age
 ≤500.66 (0.39, 1.14)0.141.29 (0.87, 1.92)0.200.63 (0.30, 1.34)0.231.25 (0.74, 2.12)0.41
 >500.57 (0.41, 0.78)<0.011.24 (0.97, 1.58)0.090.90 (0.60, 1.34)0.600.97 (0.72, 1.32)0.86
Gender
 Female1.15 (0.46, 1.76)0.770.94 (0.56, 1.56)0.801.12 (0.43, 2.97)0.821.08 (0.59, 1.98)0.81
 Male0.55 (0.40, 0.75)<0.011.29 (1.02, 1.65)0.040.87 (0.58, 1.31)0.511.08 (0.80, 1.47)0.61
Smoking status
 Never0.83 (0.55, 1.24)0.351.16 (0.84, 1.60)0.360.80 (0.46, 1.39)0.421.07 (0.72, 1.58)0.75
 Ever0.43 (0.29, 0.63)<0.011.40 (1.05, 1.85)0.020.94 (0.59, 1.49)0.791.14 (0.79, 1.65)0.47
Drinking status
 Never0.60 (0.42, 0.86)<0.011.29 (0.99, 1.68)0.060.71 (0.46, 1.08)0.110.85 (0.61, 1.18)0.32
 Ever0.50 (0.31, 0.79)<0.011.31 (0.92, 1.87)0.131.52 (0.77, 2.99)0.231.78 (1.12, 2.85)0.02
Family history of GC
 No0.58 (0.43, 0.79)<0.011.33 (1.06, 1.66)0.020.85 (0.58, 1.26)0.420.99 (0.75, 1.32)0.96
 Yes0.53 (0.26, 1.09)0.081.06 (0.61, 1.84)0.841.01 (0.42, 2.45)0.982.01 (0.86, 4.67)0.11

GC: gastric cancer; SNP: single-nucleotide polymorphism; OR: odds ratio; CI: confidence interval. aOR with 95% CI and value for logistic regression analysis adjusted for smoking, drinking, and family history of GC.

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