Associations of Functional MicroRNA Binding Site Polymorphisms in IL23/Th17 Inflammatory Pathway Genes with Gastric Cancer Risk
Table 5
Stratification analysis of the four miRNA binding site SNPs and GC susceptibility.
Variables
rs3748067
rs10889677
rs1468488
rs887796
OR (95% CI)a
a
OR (95% CI)a
a
OR (95% CI)a
a
OR (95% CI)a
a
Age
≤50
0.66 (0.39, 1.14)
0.14
1.29 (0.87, 1.92)
0.20
0.63 (0.30, 1.34)
0.23
1.25 (0.74, 2.12)
0.41
>50
0.57 (0.41, 0.78)
<0.01
1.24 (0.97, 1.58)
0.09
0.90 (0.60, 1.34)
0.60
0.97 (0.72, 1.32)
0.86
Gender
Female
1.15 (0.46, 1.76)
0.77
0.94 (0.56, 1.56)
0.80
1.12 (0.43, 2.97)
0.82
1.08 (0.59, 1.98)
0.81
Male
0.55 (0.40, 0.75)
<0.01
1.29 (1.02, 1.65)
0.04
0.87 (0.58, 1.31)
0.51
1.08 (0.80, 1.47)
0.61
Smoking status
Never
0.83 (0.55, 1.24)
0.35
1.16 (0.84, 1.60)
0.36
0.80 (0.46, 1.39)
0.42
1.07 (0.72, 1.58)
0.75
Ever
0.43 (0.29, 0.63)
<0.01
1.40 (1.05, 1.85)
0.02
0.94 (0.59, 1.49)
0.79
1.14 (0.79, 1.65)
0.47
Drinking status
Never
0.60 (0.42, 0.86)
<0.01
1.29 (0.99, 1.68)
0.06
0.71 (0.46, 1.08)
0.11
0.85 (0.61, 1.18)
0.32
Ever
0.50 (0.31, 0.79)
<0.01
1.31 (0.92, 1.87)
0.13
1.52 (0.77, 2.99)
0.23
1.78 (1.12, 2.85)
0.02
Family history of GC
No
0.58 (0.43, 0.79)
<0.01
1.33 (1.06, 1.66)
0.02
0.85 (0.58, 1.26)
0.42
0.99 (0.75, 1.32)
0.96
Yes
0.53 (0.26, 1.09)
0.08
1.06 (0.61, 1.84)
0.84
1.01 (0.42, 2.45)
0.98
2.01 (0.86, 4.67)
0.11
GC: gastric cancer; SNP: single-nucleotide polymorphism; OR: odds ratio; CI: confidence interval. aOR with 95% CI and value for logistic regression analysis adjusted for smoking, drinking, and family history of GC.
