Saquinavir Ameliorates Liver Warm Ischemia-Reperfusion-Induced Lung Injury via HMGB-1- and P38/JNK-Mediated TLR-4-Dependent Signaling Pathways

<div>P38 and JNK inhibitors could make little difference on HMGB1 protein level in lung tissue but still relieve the lung injury induced by liver I/R. H&amp;E staining and histological alterations of lung parenchyma were shown (a, b). Degree of lung edema and permeability were reflected by W/D ratio, total cell counts, and protein concentration in BALF (c, d). HMGB1 from both inhibitors with or without treatment of lung tissue was also checked (e, f). 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Mediators of Inflammation

fig8

Figure 8

Figure 8: Saquinavir Ameliorates Liver Warm Ischemia-Reperfusion-Induced Lung Injury via HMGB-1- and P38/JNK-Mediated TLR-4-Dependent Signaling Pathways 

Figure 8 | Saquinavir Ameliorates Liver Warm Ischemia-Reperfusion-Induced Lung Injury via HMGB-1- and P38/JNK-Mediated TLR-4-Dependent Signaling Pathways 