Osteopontin Augments M2 Microglia Response and Separates M1- and M2-Polarized Microglial Activation in Permanent Focal Cerebral Ischemia

<div>OPN modulates the infiltration of microglia subpopulations into distinct infarct subareas (part I: Iba1 and iNOS). All microglia stained with Iba1+ (a) and proinflammatory microglia stained with iNOS (b) shown in distinct subareas of the photothrombotic infarct after OPN treatment compared to control. Iba1+ cells are found elevated the outer infarct core, while iNOS+ cells (M1) are decreased in the infarct margin and the demarcation zone in OPN-treated animals. Scale bars represent 50 <i>μ</i>m. 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Mediators of Inflammation

fig3

Figure 3

Figure 3: Osteopontin Augments M2 Microglia Response and Separates M1- and M2-Polarized Microglial Activation in Permanent Focal Cerebral Ischemia 