Osteopontin Augments M2 Microglia Response and Separates M1- and M2-Polarized Microglial Activation in Permanent Focal Cerebral Ischemia

<div>OPN modulates the infiltration of microglia subpopulations into distinct infarct subareas (part II: Arg1 and Ym1). M2 subpopulations stained with Arg1 and Ym1 in subareas of photothrombotic infarct after OPN compared to placebo treatment. Arg1+ microglia show an increase in the outer infarct core, while Ym1+ microglia are found enriched in the outer core and infarct margin. Scale bars represent 50 <i>μ</i>m. 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Mediators of Inflammation

fig4

Figure 4

Figure 4: Osteopontin Augments M2 Microglia Response and Separates M1- and M2-Polarized Microglial Activation in Permanent Focal Cerebral Ischemia 