All-Trans Retinoic Acid Modulates TLR4/NF-<i>κ</i>B Signaling Pathway Targeting TNF-<i>α</i> and Nitric Oxide Synthase 2 Expression in Colonic Mucosa during Ulcerative Colitis and Colitis Associated Cancer

<div>Effect of LPS (10 <i>µ</i>g/ml) in the presence or absence of AtRA (10<sup>-7 </sup>M) on NOS2 (iNOS) expression in inflamed colonic mucosa of patients with active UC and CAC. AtRA reduced NOS2 expression in colonic mucosa (UC: ulcerative colitis; CAC: colitis associated cancer).</div>

Mediators of Inflammation

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Figure 13

Figure 13: All-Trans Retinoic Acid Modulates TLR4/NF-<i>κ</i>B Signaling Pathway Targeting TNF-<i>α</i> and Nitric Oxide Synthase 2 Expression in Colonic Mucosa during Ulcerative Colitis and Colitis Associated Cancer 

Figure 13 | All-Trans Retinoic Acid Modulates TLR4/NF-κB Signaling Pathway Targeting TNF-α and Nitric Oxide Synthase 2 Expression in Colonic Mucosa during Ulcerative Colitis and Colitis Associated Cancer 