The Lymphotoxin β Receptor Is Essential for Upregulation of IFN-Induced Guanylate-Binding Proteins and Survival after Toxoplasma gondii Infection

Figure 2

LTβR^−/− animals show more and larger inflammatory areas in the (a) lung and (b) liver 7 and 21 days after infection with T. gondii (ME49) cysts compared to WT animals. The lung and liver were isolated from uninfected control mice 7 and 21 days after i.p. infection with 40 T. gondii (ME49) cysts and fixed in formalin. Tissues were embedded in paraffin, 10 μm sections were generated, and HE staining was performed. Original magnification as indicated. 3 animals were analyzed for each time point, and a representative section from one organ is shown in each case. Arrows indicate small, dense lymphocyte infiltrates that are considered part of the basal LTβR^−/− phenotype. Arrowheads indicate inflammatory infiltrates seen in infected animals.

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