The Lymphotoxin β Receptor Is Essential for Upregulation of IFN-Induced Guanylate-Binding Proteins and Survival after Toxoplasma gondii Infection

Figure 4

Splenomegaly is observed only in WT but not in LTβR^−/− animals after infection with T. gondii (ME49). Mice were infected with 40 cysts and sacrificed on the days indicated. Controls were uninfected animals. (a) Spleens were isolated and weighed. (b) Cell numbers were determined by mincing and homogenizing the spleen, passing the obtained cell supension through a 40 μm cell strainer and counting live cells ( in all cases except day 30 and day 36 from LTβR^−/− animals, where only 2 animals were analyzed). , .

(a)

(b)