The Lymphotoxin β Receptor Is Essential for Upregulation of IFN-Induced Guanylate-Binding Proteins and Survival after Toxoplasma gondii Infection

Figure 8

LTβR^−/− animals show differential expression of immune relevant genes in the lung in comparison to WT animals after infection with T. gondii (ME49). Mice were sacrificed, RNA was isolated from the lungs from uninfected and infected WT and LTβR^−/− animals on the days indicated, and expression levels were determined via quantitative RT-PCR. (a) IL-12p40, (b) IFNγ, (c) iNOS, (d) GTPBP1, (e) IL-4, (f) IFNβ, (g) LTα, and (h) LTβ. ( in all cases except day 30 and day 36 from LTβR^−/− animals, where only 2 animals were analyzed).

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