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Mediators of Inflammation
Volume 2017 (2017), Article ID 7462945, 12 pages
Research Article

TSG-6 Downregulates IFN-Alpha and TNF-Alpha Expression by Suppressing IRF7 Phosphorylation in Human Plasmacytoid Dendritic Cells

Department of Paediatrics and Adolescent Medicine, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong

Correspondence should be addressed to P. P. W. Lee

Received 7 November 2016; Revised 17 January 2017; Accepted 14 February 2017; Published 6 March 2017

Academic Editor: Soh Yamazaki

Copyright © 2017 L. Kui et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Figure S1. GEN2.2 were incubated with different doses of TSG-6 (10-1000 ng/mL) over-night, followed by stimulation with CpG-A (2 uM) or R837 (10 ng/mL) for 6 hr. Supplementary Figure S2. Gating Strategy of human pDC from PBMC. Supplementary Table S1. Panel of flow-antibodies used for staining. Supplementary Table S2. Primer Sequence for Real-Time PCR

  1. Supplementary Material