Thrombopoietin Receptor Agonist Mitigates Hematopoietic Radiation Syndrome and Improves Survival after Whole-Body Ionizing Irradiation Followed by Wound Trauma

Figure 5

Different effects of Alxn4100TPO on spleen after RI or CI. (a) RI induced splenomegaly and Alxn4100TPO significantly mitigated splenomegaly but induced it after CI. (b) Wounding, RI, and CI decreased splenocyte numbers and Alxn4100TPO significantly increased them after sham, wounding, RI, and CI. (c) Each splenocyte count was normalized by its spleen weight. Spleens collected 30 days after RI and CI were weighed and then they were processed in a method to obtain resuspended cells. The numbers of splenocytes were counted. = 6 per group. Data are presented as mean ± SEM. versus Vehicle Sham; versus respective vehicle group. RI: 9.5 Gy; CI: 9.5 Gy and skin wound.

(a) Spleen weight

(b) Splenocyte counts per total spleen

(c) Splenocyte counts/mg spleen