Thrombopoietin Receptor Agonist Mitigates Hematopoietic Radiation Syndrome and Improves Survival after Whole-Body Ionizing Irradiation Followed by Wound Trauma

Figure 8

RI decreased and CI increased water consumption and Alxn4100TPO significantly decreased the CI-enhanced water consumption. The daily water consumption was monitored for 7 days after wounding, RI, or CI. = 19–22 per group. Data are presented as mean ± SEM. For panel (a): versus sham, wound, and CI; versus sham, wound, and RI; versus sham, RI, and CI. For panel (b), versus W + Vehicle. For panel (d): versus CI + Vehicle. Veh: vehicle; W: wound; RI: 9.5 Gy; CI: 9.5 Gy and skin wound.

(a) Vehicle mice

(b) Wounded mice

(c) RI mice

(d) CI mice