Osteopontin Impacts West Nile virus Pathogenesis and Resistance by Regulating Inflammasome Components and Cell Death in the Central Nervous System at Early Time Points

Figure 3

Innate immune and inflammatory cytokine transcriptional levels in the brains of WNV-infected mice. Cytokine levels were measured in the brains of perfused WT (white bars) and OPN KO (gray bars) animals, at baseline (control) and on days 3 and 5 pi. (a) INF alpha 2, (b) IFN alpha 4, (c) INF alpha 5, (d) INF beta, (e) IFN gamma, and (f) iNOS were measured by qRT-PCR. Results represent the mean ± SEM of 6 animals per group. , two-way ANOVA followed by Bonferroni’s multiple comparison test.

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