Osteopontin Impacts West Nile virus Pathogenesis and Resistance by Regulating Inflammasome Components and Cell Death in the Central Nervous System at Early Time Points

Figure 6

Transcription of IL1b and IL18 in the brain and cleaved IL1b in the plasma of WNV-infected brains. Transcriptional levels of (a) IL1b and (b) IL18 were measured by qRT-PCR, relative to GAPDH, on day 0 and day 5 post WNV infection, in WT (white bars) and in OPN KO (gray bars) brains. Results represent the mean ± SEM of 6 animals per group. , lines indicate compared groups. (c) The mature form of IL1b was detected by ELISA in the plasma of WNV-infected WT (white bars) and OPN KO (gray bars), on days 0 and 5 after infection. Results represent the mean ± SEM of 3 control WT, 6 infected WT, 3 control OPN KO, and 6 infected OPN KO. , lines indicate compared groups.

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