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Mediators of Inflammation
Volume 2017 (2017), Article ID 7586174, 13 pages
https://doi.org/10.1155/2017/7586174
Review Article

Cytokines in Endocrine Dysfunction of Plasma Cell Disorders

1CHU de Poitiers, Service d’Endocrinologie, Pole DUNE, Poitiers, France
2Université de Poitiers, UFR Médecine Pharmacie, Poitiers, France
3INSERM, CIC 1402 & U1082, Poitiers, France
4INSERM U954, Nutrition Génétique et Exposition aux Risques Environnementaux, Medical Faculty, University of Lorraine and Regional University Hospital Center of Nancy, Vandœuvre-lès-Nancy, France

Correspondence should be addressed to Eva Feigerlová

Received 12 January 2017; Accepted 25 May 2017; Published 27 June 2017

Academic Editor: Rajesh Singh

Copyright © 2017 Eva Feigerlová and Shyue-Fang Battaglia-Hsu. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Monoclonal gammopathies (MG) are classically associated with lytic bone lesions, hypercalcemia, anemia, and renal insufficiency. However, in some cases, symptoms of endocrine dysfunction are more prominent than these classical signs and misdiagnosis can thus be possible. This concerns especially the situation where the presence of M-protein is limited and the serum protein electrophoresis (sPEP) appears normal. To understand the origin of the endocrine symptoms associated with MG, we overview here the current knowledge on the complexity of interactions between cytokines and the endocrine system in MG and discuss the perspectives for both the diagnosis and treatments for this class of diseases. We also illustrate the role of major cytokines and growth factors such as IL-6, IL-1β, TNF-α, and VEGF in the endocrine system, as these tumor-relevant signaling molecules not only help the clonal expansion and invasion of the tumor cells but also influence cellular metabolism through autocrine, paracrine, and endocrine mechanisms. We further discuss the broader impact of these tumor environment-derived molecules and proinflammatory state on systemic hormone signaling. The diagnostic challenges and clinical work-up are illustrated from the point of view of an endocrinologist.