Cytokines in Endocrine Dysfunction of Plasma Cell Disorders

Table 3

Diagnostic criteria of POEMS syndrome according to Dispenzieri.

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Major criteria
Polyneuropathy
Monoclonal plasmaproliferative disorder

Minor criteria

Sclerotic bone lesion

Castleman’s disease

Organomegaly

Edema (edema, pleural effusion, and ascites)

Endocrinopathy (adrenal, thyroid, pituitary, gonadal, parathyroid, and diabetes^‡)

Skin changes (hyperpigmentation, hypertrichosis, plethora, hemangioma, and white nails)

Papilledema

Other signs
Clubbing, weight loss, hyperhidrosis, pulmonary hypertension, thrombotic diatheses, diarrhea, and low vitamin B12

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Two major criteria and at least 1 minor criterion are required for diagnosis [11]. ^‡Because of the high prevalence of diabetes mellitus and thyroid abnormalities, this diagnosis alone is not sufficient to meet this minor criterion.