Oral Administration of Resveratrol Alleviates Osteoarthritis Pathology in C57BL/6J Mice Model Induced by a High-Fat Diet

Figure 6

Schematic describing the effects and proposed response on TLR4 signaling pathway and inflammatory cytokines resulting from resveratrol treatment and HFD. HFD stimulated serum leptin level and decreased with resveratrol treatment. Leptin may upregulate CD14 via the JAK-STAT3 signaling pathway and activate CD14-dependent TLR4 pathway to induce an inflammatory response (a, dashed line). A positive feedback loop may exist between IL-1β and TLR4 pathway (b, dashed line), and resveratrol-mediated direct (c, dashed line) or indirect (d, dashed line) inhibition of TLR4 expression in cartilage could block the IL-1β-TLR4 pathway feedback loop.