S1P Lyase Regulation of Thymic Egress and Oncogenic Inflammatory Signaling

Figure 1

(a) SPL and its related diseases. (b) Besides endoplasmic reticulum, SPL is also localized in mitochondria-associated membrane (MAM). SPL present in MAM generates hexadecenal (Hex), which induces Bax activation.

(a)

(b)