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Mediators of Inflammation
Volume 2017, Article ID 7918472, 11 pages
Research Article

The Correlation between FSTL1 Expression and Airway Remodeling in Asthmatics

1Department of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan 250012, China
2Department of Pulmonary Medicine-Bronchoscopy Room, Qilu Hospital of Shandong University, Jinan 250012, China

Correspondence should be addressed to Liang Dong; moc.621@6055ld

Received 4 January 2017; Revised 6 April 2017; Accepted 19 June 2017; Published 3 August 2017

Academic Editor: Sandra Helena Penha Oliveira

Copyright © 2017 Yahui Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Asthma is characterized by airway remodeling. Follistatin-like protein 1 (FSTL1) is an extracellular glycoprotein. Recent studies suggest that FSTL1 may participate in the pathogenesis of asthma. Objectives. To analyze the association between FSTL1 and some parameters and inspect the role of FSTL1 in asthma. Methods. We examined FSTL1 levels in 32 asthmatics and 25 controls. All subjects enrolled had routine blood tests, spirometry, and impulse oscillometry performed. Additionally, 15 of the 32 asthmatics underwent fibre optic bronchoscopy. Spearman rank analysis was performed to detect the correlation between FSTL1 and other parameters. Results. Plasma FSTL1 levels were higher in asthmatics (130.762 ± 46.029 ng/mL) than in controls (95.408 ± 33.938 ng/mL) (). Plasma FSTL1 levels were associated with fibrosis levels around the airways (, ) and α-smooth muscle actin (α-SMA) (, ). FSTL1 levels in bronchoalveolar lavage fluid were associated with collagen I (, ), α-SMA (, ), fibrosis levels (, ), and the thickness of the airway reticular basement membrane (RBM) (, ). Conclusions. FSTL1 levels in asthmatics were linked with increased smooth muscle mass and thickened RBM. FSTL1 may contribute to airway remodeling in asthmatics.