Inherited Variation in Cytokine, Acute Phase Response, and Calcium Metabolism Genes Affects Susceptibility to Infective Endocarditis

Table 4

Association of the polymorphisms within the cytokine immunity genes, acute phase response genes, hemostasis genes, genes of lipid metabolism, and genes of calcium metabolism with infective endocarditis.

Model	Genotype	Without infective; endocarditis	With infective; endocarditis	OR (95% CI)	p value	AIC	HWE
IL1B rs1143634
Codominant	G/G	154 (51.3%)	82 (67.8%)	1.00	0.0029	472.5	0.89
	G/A	123 (41%)	28 (23.1%)	0.43 (0.26–0.72)
	A/A	23 (7.7%)	11 (9.1%)	0.97 (0.43–2.18)
Dominant	G/G	154 (51.3%)	82 (67.8%)	1.00	0.0036	473.8
	G/A-A/A	146 (48.7%)	39 (32.2%)	0.51 (0.32–0.81)
Recessive	G/G-G/A	277 (92.3%)	110 (90.9%)	1.00	0.52	481.8
	A/A	23 (7.7%)	11 (9.1%)	1.30 (0.59–2.88)
Overdominant	G/G-A/A	177 (59%)	93 (76.9%)	1.00	0.0016	470.6
	G/A	123 (41%)	28 (23.1%)	0.43 (0.26–0.71)
Log-additive	—	—	—	0.70 (0.48–1.00)	0.046	478.2
IL6 rs1554606
Codominant	G/G	92 (30.7%)	31 (25.4%)	1.00	0.31	483	0.99
	G/T	149 (49.7%)	62 (50.8%)	1.38 (0.82–2.33)
	T/T	59 (19.7%)	29 (23.8%)	1.57 (0.84–2.95)
Dominant	G/G	92 (30.7%)	31 (25.4%)	1.00	0.15	481.2
	G/T–T/T	208 (69.3%)	91 (74.6%)	1.44 (0.87–2.36)
Recessive	G/G-G/T	241 (80.3%)	93 (76.2%)	1.00	0.36	482.5
	T/T	59 (19.7%)	29 (23.8%)	1.28 (0.76–2.17)
Overdominant	G/G-T/T	151 (50.3%)	60 (49.2%)	1.00	0.58	483
	G/T	149 (49.7%)	62 (50.8%)	1.13 (0.73–1.76)
Log-additive	—	—	—	1.26 (0.92–1.72)	0.14	481.2
IL6 rs1800796
Codominant	G/G	260 (86.7%)	104 (85.2%)	1.00	0.98	485.3	0.64
	C/G	38 (12.7%)	17 (13.9%)	1.07 (0.56–2.02)
	C/C	2 (0.7%)	1 (0.8%)	1.17 (0.08–17.14)
Dominant	G/G	260 (86.7%)	104 (85.2%)	1.00	0.83	483.3
	C/G-C/C	40 (13.3%)	18 (14.8%)	1.07 (0.57–2.00)
Recessive	G/G-C/G	298 (99.3%)	121 (99.2%)	1.00	0.91	483.3
	C/C	2 (0.7%)	1 (0.8%)	1.16 (0.08–16.99)
Overdominant	G/G-C/C	262 (87.3%)	105 (86.1%)	1.00	0.85	483.3
	C/G	38 (12.7%)	17 (13.9%)	1.06 (0.56–2.02)
Log-additive	—	—	—	1.07 (0.60–1.92)	0.82	483.3
IL6 rs2069827
Codominant	G/G	245 (81.7%)	99 (81.2%)	1.00	0.82	484.9	0.51
	G/T	51 (17%)	22 (18%)	1.20 (0.68–2.14)
	T/T	4 (1.3%)	1 (0.8%)	0.93 (0.10–8.66)
Dominant	G/G	245 (81.7%)	99 (81.2%)	1.00	0.55	483
	G/T–T/T	55 (18.3%)	23 (18.9%)	1.19 (0.68–2.08)
Recessive	G/G-G/T	296 (98.7%)	121 (99.2%)	1.00	0.93	483.3
	T/T	4 (1.3%)	1 (0.8%)	0.90 (0.10–8.33)
Overdominant	G/G-T/T	249 (83%)	100 (82%)	1.00	0.53	482.9
	G/T	51 (17%)	22 (18%)	1.20 (0.68–2.14)
Log-additive	—	—	—	1.15 (0.69–1.92)	0.6	483.1
IL6R rs2228145
Codominant	A/A	144 (48%)	62 (50.8%)	1.00	0.46	483.8	0.89
	C/A	127 (42.3%)	45 (36.9%)	0.84 (0.52–1.34)
	C/C	29 (9.7%)	15 (12.3%)	1.32 (0.64–2.73)
Dominant	A/A	144 (48%)	62 (50.8%)	1.00	0.71	483.2
	C/A-C/C	156 (52%)	60 (49.2%)	0.92 (0.59–1.43)
Recessive	A/A-C/A	271 (90.3%)	107 (87.7%)	1.00	0.32	482.3
	C/C	29 (9.7%)	15 (12.3%)	1.43 (0.72–2.87)
Overdominant	A/A-C/C	173 (57.7%)	77 (63.1%)	1.00	0.32	482.3
	C/A	127 (42.3%)	45 (36.9%)	0.79 (0.51–1.25)
Log-additive	—	—	—	1.03 (0.74–1.43)	0.85	483.3
IL6R rs2229238
Codominant	C/C	158 (52.7%)	62 (50.8%)	1.00	0.48	483.8	0.88
	C/T	121 (40.3%)	47 (38.5%)	1.00 (0.63–1.60)
	T/T	21 (7%)	13 (10.7%)	1.63 (0.73–3.61)
Dominant	C/C	158 (52.7%)	62 (50.8%)	1.00	0.69	483.2
	C/T–T/T	142 (47.3%)	60 (49.2%)	1.09 (0.71–1.70)
Recessive	C/C-C/T	279 (93%)	109 (89.3%)	1.00	0.22	481.8
	T/T	21 (7%)	13 (10.7%)	1.63 (0.75–3.51)
Overdominant	C/C-T/T	179 (59.7%)	75 (61.5%)	1.00	0.78	483.3
	C/T	121 (40.3%)	47 (38.5%)	0.94 (0.60–1.47)
Log-additive	—	—	—	1.16 (0.82–1.63)	0.4	482.6
IL8 rs2227306
Codominant	C/C	100 (33.3%)	49 (40.2%)	1.00	0.42	483.6	0.99
	C/T	147 (49%)	59 (48.4%)	0.83 (0.52–1.33)
	T/T	53 (17.7%)	14 (11.5%)	0.63 (0.31–1.28)
Dominant	C/C	100 (33.3%)	49 (40.2%)	1.00	0.29	482.2
	C/T–T/T	200 (66.7%)	73 (59.8%)	0.78 (0.50–1.23)
Recessive	C/C-C/T	247 (82.3%)	108 (88.5%)	1.00	0.28	482.2
	T/T	53 (17.7%)	14 (11.5%)	0.70 (0.37–1.35)
Overdominant	C/C-T/T	153 (51%)	63 (51.6%)	1.00	0.79	483.3
	C/T	147 (49%)	59 (48.4%)	0.94 (0.61–1.46)
Log-additive	—	—	—	0.80 (0.58–1.12)	0.19	481.6
IL10 rs1800871
Codominant	G/G	183 (61%)	69 (56.6%)	1.00	0.88	485.1	0.61
	A/G	105 (35%)	47 (38.5%)	1.12 (0.71–1.78)
	A/A	12 (4%)	6 (4.9%)	0.98 (0.34–2.81)
Dominant	G/G	183 (61%)	69 (56.6%)	1.00	0.66	483.1
	A/G-A/A	117 (39%)	53 (43.4%)	1.11 (0.71–1.73)
Recessive	G/G-A/G	288 (96%)	116 (95.1%)	1.00	0.9	483.3
	A/A	12 (4%)	6 (4.9%)	0.94 (0.33–2.64)
Overdominant	G/G-A/A	195 (65%)	75 (61.5%)	1.00	0.61	483.1
	A/G	105 (35%)	47 (38.5%)	1.13 (0.71–1.77)
Log-additive	—	—	—	1.06 (0.73–1.55)	0.74	483.2
IL10 rs1800872
Codominant	G/G	185 (62.1%)	67 (55.4%)	1.00	0.55	481.3	0.86
	T/G	101 (33.9%)	49 (40.5%)	1.27 (0.80–2.01)
	T/T	12 (4%)	5 (4.1%)	0.86 (0.28–2.61)
Dominant	G/G	185 (62.1%)	67 (55.4%)	1.00	0.39	479.8
	T/G-T/T	113 (37.9%)	54 (44.6%)	1.22 (0.78–1.90)
Recessive	G/G-T/G	286 (96%)	116 (95.9%)	1.00	0.65	480.3
	T/T	12 (4%)	5 (4.1%)	0.78 (0.26–2.34)
Overdominant	G/G-T/T	197 (66.1%)	72 (59.5%)	1.00	0.29	479.4
	T/G	101 (33.9%)	49 (40.5%)	1.28 (0.81–2.01)
Log-additive	—	—	—	1.11 (0.76–1.63)	0.57	480.2
IL10 rs1800896
Codominant	T/T	88 (29.3%)	34 (28.1%)	1.00	0.82	481.7	0.35
	T/C	157 (52.3%)	66 (54.5%)	1.17 (0.70–1.95)
	C/C	55 (18.3%)	21 (17.4%)	1.17 (0.59–2.29)
Dominant	T/T	88 (29.3%)	34 (28.1%)	1.00	0.53	479.7
	T/C-C/C	212 (70.7%)	87 (71.9%)	1.17 (0.71–1.91)
Recessive	T/T–T/C	245 (81.7%)	100 (82.6%)	1.00	0.87	480
	C/C	55 (18.3%)	21 (17.4%)	1.05 (0.59–1.88)
Overdominant	T/T-C/C	143 (47.7%)	55 (45.5%)	1.00	0.66	479.9
	T/C	157 (52.3%)	66 (54.5%)	1.10 (0.71–1.72)
Log-additive	—	—	—	1.09 (0.78–1.52)	0.61	479.8
IL12B rs3212227
Codominant	T/T	191 (63.7%)	86 (70.5%)	1.00	0.076	480.2	0.86
	G/T	96 (32%)	29 (23.8%)	0.57 (0.34–0.96)
	G/G	13 (4.3%)	7 (5.7%)	1.20 (0.45–3.24)
Dominant	T/T	191 (63.7%)	86 (70.5%)	1.00	0.067	480
	G/T-G/G	109 (36.3%)	36 (29.5%)	0.64 (0.40–1.04)
Recessive	T/T-G/T	287 (95.7%)	115 (94.3%)	1.00	0.5	482.9
	G/G	13 (4.3%)	7 (5.7%)	1.41 (0.53–3.75)
Overdominant	T/T-G/G	204 (68%)	93 (76.2%)	1.00	0.025	478.3
	G/T	96 (32%)	29 (23.8%)	0.57 (0.34–0.94)
Log-additive	—	—	—	0.78 (0.53–1.16)	0.21	481.8
IL12RB rs375947
Codominant	A/A	137 (45.7%)	53 (43.4%)	1.00	0.58	484.3	0.60
	A/G	135 (45%)	55 (45.1%)	1.18 (0.74–1.89)
	G/G	28 (9.3%)	14 (11.5%)	1.44 (0.68–3.03)
Dominant	A/A	137 (45.7%)	53 (43.4%)	1.00	0.37	482.5
	A/G-G/G	163 (54.3%)	69 (56.6%)	1.23 (0.79–1.91)
Recessive	A/A-A/G	272 (90.7%)	108 (88.5%)	1.00	0.45	482.7
	G/G	28 (9.3%)	14 (11.5%)	1.32 (0.65–2.68)
Overdominant	A/A-G/G	165 (55%)	67 (54.9%)	1.00	0.66	483.1
	A/G	135 (45%)	55 (45.1%)	1.10 (0.71–1.72)
Log-additive	—	—	—	1.19 (0.85–1.67)	0.3	482.3
TNF rs361525
Codominant	G/G	274 (91.3%)	112 (91.8%)	1.00	0.81	484.9	0.46
	A/G	25 (8.3%)	10 (8.2%)	0.90 (0.40–1.99)
	A/A	1 (0.3%)	0 (0%)	0.00 (0.00–NA)
Dominant	G/G	274 (91.3%)	112 (91.8%)	1.00	0.74	483.2
	A/G-A/A	26 (8.7%)	10 (8.2%)	0.88 (0.39–1.94)
Recessive	G/G-A/G	299 (99.7%)	122 (100%)	1.00	0.55	483
	A/A	1 (0.3%)	0 (0%)	0.00 (0.00–NA)
Overdominant	G/G-A/A	275 (91.7%)	112 (91.8%)	1.00	0.79	483.3
	A/G	25 (8.3%)	10 (8.2%)	0.90 (0.40–2.00)
Log-additive	—	—	—	0.86 (0.39–1.87)	0.7	483.2
TNF rs1800629
Codominant	G/G	229 (76.3%)	97 (79.5%)	1.00	0.66	484.5	0.99
	A/G	67 (22.3%)	24 (19.7%)	0.89 (0.51–1.54)
	A/A	4 (1.3%)	1 (0.8%)	0.41 (0.04–3.93)
Dominant	G/G	229 (76.3%)	97 (79.5%)	1.00	0.56	483
	A/G-A/A	71 (23.7%)	25 (20.5%)	0.85 (0.50–1.46)
Recessive	G/G-A/G	296 (98.7%)	121 (99.2%)	1.00	0.42	482.7
	A/A	4 (1.3%)	1 (0.8%)	0.42 (0.04–4.02)
Overdominant	G/G-A/A	233 (77.7%)	98 (80.3%)	1.00	0.71	483.2
	A/G	67 (22.3%)	24 (19.7%)	0.90 (0.52–1.55)
Log-additive	—	—	—	0.83 (0.51–1.37)	0.47	482.8
CRP rs3093077
Codominant	C/C	262 (87.3%)	112 (92.6%)	1.00	0.28	481.5	0.99
	A/C	37 (12.3%)	8 (6.6%)	0.55 (0.24–1.23)
	A/A	1 (0.3%)	1 (0.8%)	1.99 (0.12–34.12)
Dominant	C/C	262 (87.3%)	112 (92.6%)	1.00	0.17	480.2
	A/C-A/A	38 (12.7%)	9 (7.4%)	0.59 (0.27–1.29)
Recessive	C/C-A/C	299 (99.7%)	120 (99.2%)	1.00	0.61	481.8
	A/A	1 (0.3%)	1 (0.8%)	2.10 (0.12–36.04)
Overdominant	C/C-A/A	263 (87.7%)	113 (93.4%)	1.00	0.13	479.7
	A/C	37 (12.3%)	8 (6.6%)	0.55 (0.24–1.23)
Log-additive	—	—	—	0.67 (0.33–1.36)	0.25	480.7
CRP rs1130864
Codominant	G/G	142 (47.3%)	68 (55.7%)	1.00	0.018	477.9	0.41
	A/G	134 (44.7%)	38 (31.1%)	0.58 (0.36–0.93)
	A/A	24 (8%)	16 (13.1%)	1.45 (0.70–3.00)
Dominant	G/G	142 (47.3%)	68 (55.7%)	1.00	0.12	481.4
	A/G-A/A	158 (52.7%)	54 (44.3%)	0.71 (0.45–1.09)
Recessive	G/G-A/G	276 (92%)	106 (86.9%)	1.00	0.094	481.1
	A/A	24 (8%)	16 (13.1%)	1.83 (0.91–3.69)
Overdominant	G/G-A/A	166 (55.3%)	84 (68.8%)	1.00	0.0083	476.9
	A/G	134 (44.7%)	38 (31.1%)	0.54 (0.34–0.86)
Log-additive	—	—	—	0.93 (0.67–1.30)	0.68	483.7
CRP rs1205
Codominant	C/C	112 (37.3%)	38 (31.9%)	1.00	0.018	468.4	0.11
	C/T	154 (51.3%)	56 (47.1%)	1.06 (0.64–1.74)
	T/T	34 (11.3%)	25 (21%)	2.50 (1.28–4.90)
Dominant	C/C	112 (37.3%)	38 (31.9%)	1.00	0.28	473.3
	C/T–T/T	188 (62.7%)	81 (68.1%)	1.29 (0.81–2.07)
Recessive	C/C-C/T	266 (88.7%)	94 (79%)	1.00	0.0047	466.5
	T/T	34 (11.3%)	25 (21%)	2.42 (1.32–4.43)
Overdominant	C/C-T/T	146 (48.7%)	63 (52.9%)	1.00	0.34	473.6
	C/T	154 (51.3%)	56 (47.1%)	0.80 (0.52–1.25)
Log-additive	—	—	—	1.47 (1.05–2.05)	0.023	469.3
APOB rs1042031
Codominant	C/C	210 (70.5%)	83 (69.8%)	1.00	0.86	477.7	0.40
	C/T	78 (26.2%)	33 (27.7%)	1.00 (0.61–1.65)
	T/T	10 (3.4%)	3 (2.5%)	0.69 (0.18–2.71)
Dominant	C/C	210 (70.5%)	83 (69.8%)	1.00	0.88	476
	C/T–T/T	88 (29.5%)	36 (30.2%)	0.96 (0.59–1.56)
Recessive	C/C-C/T	288 (96.6%)	116 (97.5%)	1.00	0.59	475.7
	T/T	10 (3.4%)	3 (2.5%)	0.69 (0.18–2.69)
Overdominant	C/C-T/T	220 (73.8%)	86 (72.3%)	1.00	0.95	476
	C/T	78 (26.2%)	33 (27.7%)	1.01 (0.62–1.67)
Log-additive	—	—	—	0.94 (0.62–1.42)	0.76	475.9
APOB rs6725189
Codominant	G/G	196 (65.8%)	72 (59.5%)	1.00	0.53	481.2	0.46
	G/T	89 (29.9%)	44 (36.4%)	1.31 (0.82–2.10)
	T/T	13 (4.4%)	5 (4.1%)	1.01 (0.33–3.04)
Dominant	G/G	196 (65.8%)	72 (59.5%)	1.00	0.3	479.4
	G/T–T/T	102 (34.2%)	49 (40.5%)	1.27 (0.81–2.00)
Recessive	G/G-G/T	285 (95.6%)	116 (95.9%)	1.00	0.87	480.5
	T/T	13 (4.4%)	5 (4.1%)	0.92 (0.31–2.73)
Overdominant	G/G-T/T	209 (70.1%)	77 (63.6%)	1.00	0.26	479.2
	G/T	89 (29.9%)	44 (36.4%)	1.31 (0.82–2.08)
Log-additive	—	—	—	1.17 (0.80–1.71)	0.42	479.9
APOE rs7412
Codominant	C/C	251 (83.7%)	104 (86%)	1.00	0.63	483.2	0.71
	C/T	48 (16%)	16 (13.2%)	0.79 (0.42–1.49)
	T/T	1 (0.3%)	1 (0.8%)	2.37 (0.13–43.65)
Dominant	C/C	251 (83.7%)	104 (86%)	1.00	0.53	481.7
	C/T–T/T	49 (16.3%)	17 (14.1%)	0.82 (0.44–1.53)
Recessive	C/C-C/T	299 (99.7%)	120 (99.2%)	1.00	0.55	481.7
	T/T	1 (0.3%)	1 (0.8%)	2.45 (0.13–45.09)
Overdominant	C/C-T/T	252 (84%)	105 (86.8%)	1.00	0.44	481.5
	C/T	48 (16%)	16 (13.2%)	0.78 (0.42–1.48)
Log-additive	—	—	—	0.86 (0.48–1.56)	0.63	481.8
APOE rs429358
Codominant	T/T	239 (79.7%)	96 (78.7%)	1.00	0.71	485.2	0.99
	C/T	58 (19.3%)	24 (19.7%)	1.22 (0.70–2.14)
	C/C	3 (1%)	2 (1.6%)	1.58 (0.24–10.40)
Dominant	T/T	239 (79.7%)	96 (78.7%)	1.00	0.44	483.3
	C/T-C/C	61 (20.3%)	26 (21.3%)	1.24 (0.72–2.14)
Recessive	T/T-C/T	297 (99%)	120 (98.4%)	1.00	0.67	483.7
	C/C	3 (1%)	2 (1.6%)	1.52 (0.23–9.97)
Overdominant	T/T-C/C	242 (80.7%)	98 (80.3%)	1.00	0.5	483.4
	C/T	58 (19.3%)	24 (19.7%)	1.21 (0.69–2.12)
Log-additive	—	—	—	1.23 (0.75–2.01)	0.41	483.2
LIPC rs1800588
Codominant	C/C	173 (57.7%)	77 (63.6%)	1.00	0.2	480.8	0.52
	C/T	113 (37.7%)	41 (33.9%)	0.69 (0.43–1.11)
	T/T	14 (4.7%)	3 (2.5%)	0.48 (0.13–1.81)
Dominant	C/C	173 (57.7%)	77 (63.6%)	1.00	0.084	479.1
	C/T–T/T	127 (42.3%)	44 (36.4%)	0.67 (0.43–1.06)
Recessive	C/C-C/T	286 (95.3%)	118 (97.5%)	1.00	0.35	481.2
	T/T	14 (4.7%)	3 (2.5%)	0.55 (0.15–2.03)
Overdominant	C/C-T/T	187 (62.3%)	80 (66.1%)	1.00	0.16	480.1
	C/T	113 (37.7%)	41 (33.9%)	0.72 (0.45–1.15)
Log-additive	—	—	—	0.69 (0.46–1.04)	0.071	478.8
LPA rs10455872
—	A/A	275 (92%)	108 (91.5%)	1.00	0.86	475.8	0.99
	A/G	24 (8%)	10 (8.5%)	1.08 (0.48–2.39)
NOTCH1 rs13290979
Codominant	A/A	98 (32.8%)	53 (43.8%)	1.00	0.024	476.2	0.48
	A/G	152 (50.8%)	44 (36.4%)	0.53 (0.33–0.87)
	G/G	49 (16.4%)	24 (19.8%)	0.98 (0.53–1.82)
Dominant	A/A	98 (32.8%)	53 (43.8%)	1.00	0.05	477.9
	A/G-G/G	201 (67.2%)	68 (56.2%)	0.64 (0.41–1.00)
Recessive	A/A-A/G	250 (83.6%)	97 (80.2%)	1.00	0.28	480.6
	G/G	49 (16.4%)	24 (19.8%)	1.37 (0.78–2.41)
Overdominant	A/A-G/G	147 (49.2%)	77 (63.6%)	1.00	0.0062	474.2
	A/G	152 (50.8%)	44 (36.4%)	0.54 (0.34–0.84)
Log-additive	—	—	—	0.88 (0.65–1.21)	0.44	481.1
VDR rs2228570
Codominant	G/G	94 (31.5%)	36 (29.8%)	1.00	0.19	479.1	0.81
	A/G	145 (48.7%)	51 (42.1%)	0.93 (0.55–1.57)
	A/A	59 (19.8%)	34 (28.1%)	1.54 (0.85–2.80)
Dominant	G/G	94 (31.5%)	36 (29.8%)	1.00	0.67	480.3
	A/G-A/A	204 (68.5%)	85 (70.2%)	1.11 (0.69–1.79)
Recessive	G/G-A/G	239 (80.2%)	87 (71.9%)	1.00	0.07	477.2
	A/A	59 (19.8%)	34 (28.1%)	1.61 (0.97–2.68)
Overdominant	G/G-A/A	153 (51.3%)	70 (57.9%)	1.00	0.25	479.2
	A/G	145 (48.7%)	51 (42.1%)	0.77 (0.50–1.20)
Log-additive	—	—	—	1.23 (0.91–1.66)	0.19	478.8
CASR rs1042636
Codominant	A/A	244 (81.6%)	103 (85.1%)	1.00	0.2	480.5	0.75
	A/G	52 (17.4%)	18 (14.9%)	0.71 (0.39–1.30)
	G/G	3 (1%)	0 (0%)	0.00 (0.00–NA)
Dominant	A/A	244 (81.6%)	103 (85.1%)	1.00	0.19	480
	A/G-G/G	55 (18.4%)	18 (14.9%)	0.67 (0.37–1.23)
Recessive	A/A-A/G	296 (99%)	121 (100%)	1.00	0.16	479.8
	G/G	3 (1%)	0 (0%)	0.00 (0.00–NA)
Overdominant	A/A-G/G	247 (82.6%)	103 (85.1%)	1.00	0.28	480.5
	A/G	52 (17.4%)	18 (14.9%)	0.72 (0.39–1.32)
Log-additive	—	—	—	0.65 (0.37–1.17)	0.14	479.6
OPG rs3134069
Codominant	A/A	248 (83.2%)	110 (90.9%)	1.00	0.19	479.2	0.71
	A/C	49 (16.4%)	10 (8.3%)	0.53 (0.25–1.11)
	C/C	1 (0.3%)	1 (0.8%)	1.92 (0.09–41.36)
Dominant	A/A	248 (83.2%)	110 (90.9%)	1.00	0.1	477.9
	A/C-C/C	50 (16.8%)	11 (9.1%)	0.56 (0.28–1.15)
Recessive	A/A-A/C	297 (99.7%)	120 (99.2%)	1.00	0.65	480.3
	C/C	1 (0.3%)	1 (0.8%)	2.06 (0.09–44.96)
Overdominant	A/A-C/C	249 (83.6%)	111 (91.7%)	1.00	0.078	477.4
	A/C	49 (16.4%)	10 (8.3%)	0.53 (0.25–1.11)
Log-additive	—	—	—	0.62 (0.32–1.21)	0.15	478.4
OPG rs2073618
Codominant	C/C	76 (25.4%)	32 (26.7%)	1.00	0.17	478.3	0.56
	C/G	155 (51.8%)	51 (42.5%)	0.79 (0.46–1.36)
	G/G	68 (22.7%)	37 (30.8%)	1.32 (0.73–2.41)
Dominant	C/C	76 (25.4%)	32 (26.7%)	1.00	0.86	479.9
	C/G-G/G	223 (74.6%)	88 (73.3%)	0.96 (0.58–1.58)
Recessive	C/C-C/G	231 (77.3%)	83 (69.2%)	1.00	0.089	477
	G/G	68 (22.7%)	37 (30.8%)	1.54 (0.94–2.52)
Overdominant	C/C-G/G	144 (48.2%)	69 (57.5%)	1.00	0.098	477.2
	C/G	155 (51.8%)	51 (42.5%)	0.69 (0.44–1.07)
Log-additive	—	—	—	1.16 (0.85–1.58)	0.35	479
OPG rs3102735
Codominant	T/T	218 (73.2%)	95 (78.5%)	1.00	0.36	480.4	0.82
	C/T	73 (24.5%)	25 (20.7%)	0.89 (0.52–1.52)
	C/C	7 (2.4%)	1 (0.8%)	0.25 (0.03–2.27)
Dominant	T/T	218 (73.2%)	95 (78.5%)	1.00	0.46	480
	C/T-C/C	80 (26.9%)	26 (21.5%)	0.82 (0.49–1.39)
Recessive	T/T-C/T	291 (97.7%)	120 (99.2%)	1.00	0.17	478.6
	C/C	7 (2.4%)	1 (0.8%)	0.26 (0.03–2.32)
Overdominant	T/T-C/C	225 (75.5%)	96 (79.3%)	1.00	0.74	480.4
	C/T	73 (24.5%)	25 (20.7%)	0.91 (0.53–1.56)
Log-additive	—	—	—	0.78 (0.49–1.26)	0.3	479.4
CALCR rs1801197
Codominant	A/A	140 (46.8%)	76 (62.8%)	1.00	0.0077	474	0.22
	A/G	136 (45.5%)	40 (33.1%)	0.52 (0.33–0.84)
	G/G	23 (7.7%)	5 (4.1%)	0.36 (0.13–1.03)
Dominant	A/A	140 (46.8%)	76 (62.8%)	1.00	0.0024	472.5
	A/G-G/G	159 (53.2%)	45 (37.2%)	0.50 (0.32–0.79)
Recessive	A/A-A/G	276 (92.3%)	116 (95.9%)	1.00	0.13	479.5
	G/G	23 (7.7%)	5 (4.1%)	0.48 (0.17–1.33)
Overdominant	A/A-G/G	163 (54.5%)	81 (66.9%)	1.00	0.018	476.2
	A/G	136 (45.5%)	40 (33.1%)	0.58 (0.36–0.92)
Log-additive	—	—	—	0.56 (0.38–0.82)	0.002	472.2
F2 rs1799963
—	G/G	286 (95.7%)	118 (98.3%)	1.00	0.10	477	0.99
	A/G	13 (4.3%)	2 (1.7%)	0.32 (0.07–1.49)
F5 rs6025
Codominant	C/C	286 (95.7%)	117 (97.5%)	1.00	0.32	479.4	0.14
	C/T	12 (4%)	3 (2.5%)	0.56 (0.15–2.11)
	T/T	1 (0.3%)	0 (0%)	0.00 (0.00–NA)
Dominant	C/C	286 (95.7%)	117 (97.5%)	1.00	0.24	478.3
	C/T–T/T	13 (4.3%)	3 (2.5%)	0.48 (0.13–1.79)
Recessive	C/C-C/T	298 (99.7%)	120 (100%)	1.00	0.23	478.2
	T/T	1 (0.3%)	0 (0%)	0.00 (0.00–NA)
Overdominant	C/C-T/T	287 (96%)	117 (97.5%)	1.00	0.38	478.9
	C/T	12 (4%)	3 (2.5%)	0.57 (0.15–2.13)
Log-additive	—	—	—	0.47 (0.14–1.58)	0.19	477.9
F5 rs6027
Codominant	T/T	254 (85%)	104 (86.7%)	1.00	0.35	479.5	0.12
	C/T	41 (13.7%)	16 (13.3%)	1.00 (0.52–1.91)
	C/C	4 (1.3%)	0 (0%)	0.00 (0.00–NA)
Dominant	T/T	254 (85%)	104 (86.7%)	1.00	0.79	479.6
	C/T-C/C	45 (15.1%)	16 (13.3%)	0.92 (0.48–1.74)
Recessive	T/T-C/T	295 (98.7%)	120 (100%)	1.00	0.15	477.5
	C/C	4 (1.3%)	0 (0%)	0.00 (0.00–NA)
Overdominant	T/T-C/C	258 (86.3%)	104 (86.7%)	1.00	0.98	479.6
	C/T	41 (13.7%)	16 (13.3%)	1.01 (0.53–1.93)
Log-additive	—	—	—	0.86 (0.47–1.56)	0.61	479.4
F7 rs6046
Codominant	G/G	236 (78.9%)	88 (72.7%)	1.00	0.06	477.8	0.77
	A/G	59 (19.7%)	33 (27.3%)	1.58 (0.94–2.64)
	A/A	4 (1.3%)	0 (0%)	0.00 (0.00–NA)
Dominant	G/G	236 (78.9%)	88 (72.7%)	1.00	0.14	479.2
	A/G-A/A	63 (21.1%)	33 (27.3%)	1.48 (0.89–2.46)
Recessive	G/G-A/G	295 (98.7%)	121 (100%)	1.00	0.1	478.8
	A/A	4 (1.3%)	0 (0%)	0.00 (0.00–NA)
Overdominant	G/G-A/A	240 (80.3%)	88 (72.7%)	1.00	0.074	478.2
	A/G	59 (19.7%)	33 (27.3%)	1.60 (0.96–2.68)
Log-additive	—	—	—	1.32 (0.82–2.14)	0.26	480.1
ITGB3 rs5918
Codominant	T/T	214 (71.6%)	88 (73.3%)	1.00	0.5	480.2	0.66
	C/T	77 (25.8%)	26 (21.7%)	0.84 (0.49–1.43)
	C/C	8 (2.7%)	6 (5%)	1.69 (0.55–5.19)
Dominant	T/T	214 (71.6%)	88 (73.3%)	1.00	0.76	479.5
	C/T-C/C	85 (28.4%)	32 (26.7%)	0.93 (0.56–1.52)
Recessive	T/T-C/T	291 (97.3%)	114 (95%)	1.00	0.32	478.6
	C/C	8 (2.7%)	6 (5%)	1.77 (0.58–5.39)
Overdominant	T/T-C/C	222 (74.2%)	94 (78.3%)	1.00	0.45	479
	C/T	77 (25.8%)	26 (21.7%)	0.82 (0.48–1.38)
Log-additive	—	—	—	1.02 (0.68–1.54)	0.92	479.6

All the ORs and 95% CIs are adjusted for age and gender. IL: interleukin; TNF: tumor necrosis factor; CRP: C-reactive protein; APO: apolipoprotein; LIPC: hepatic lipase; LPA: lipoprotein (a); VDR: vitamin D receptor; CASR: calcium-sensing receptor; OPG: osteoprotegerin; CALCR: calcitonin receptor; ITGB: integrin beta; OR: odds ratio; CI: confidence interval; AIC: Akaike information criterion; HWE: Hardy-Weinberg equilibrium.