Taenia crassiceps Antigens Control Experimental Type 1 Diabetes by Inducing Alternatively Activated Macrophages

Figure 2

Constant TcS exposure reduces insulitis in MLD-STZ-treated mice. T1D-induced mice were treated with TcS for 6 weeks. The animals were sacrificed, and the pancreases were processed, embedded in paraffin, and cut into 5 μm sections. (a) Representative pictures of islets of Langerhans stained with H&E and evaluated microscopically for the presence of insulitis. Arrows show cellular infiltrate in islets of Langerhans. Magnification of 400x. (b) Percentage of insulitis. Score of infiltrated islets. Noninfiltrated: without damage. Peri-insulitis: infiltration only at the periphery of the islets. Insulitis 20%: infiltration of ≥20% or more but less than 40%. Insulitis 40%: infiltrate of ≥40% of islets. The insulitis evaluation shown is representative of 10 mice per group (at least 100 islets were counted).

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