Review Article
The Role of Tissue Macrophage-Mediated Inflammation on NAFLD Pathogenesis and Its Clinical Implications
Table 1
Typical surface markers and functions in M1 and M2 macrophages.
| M1 markers | Major function | Ref. |
| CD80 (B7-1) | T cell activation and survival | [15] | CD86 (B7-2) | T cell activation and survival | [15] | MHC-II | Exogenous antigen presentation | [15] | CD11c | Phagocytosis | [17] | TLR4 | Pathogen recognition | [18] | Mincle | Phagocytosis and proinflammatory cytokines | [18] |
| M2 markers | Major function | ā |
| CD206 | Phagocytosis, antigen presentation, and resolution of inflammation | [19] | CD163 | Tolerance induction and tissue regeneration | [15] | Dectin-1 | Chemotaxis | [15] | CD301 | Cell adhesion, cell-cell signalling, and glycoprotein turnover | [21] | Arginase-1 | Suppression of clearance of intracellular pathogens | [15]
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