Research Article
Urinary Levels of IL-1β and GDNF in Preterm Neonates as Potential Biomarkers of Motor Development: A Prospective Study
Table 5
Association between clinical features, urinary levels of inflammatory markers and neurotrophic factors and motor development results in TIMP.
| | Variables | Motor development | | T1 | T2 | T3 | Lower than expected
() | Typical development
() | | Lower than expected
() | Typical development
() | | Lower than expected
() | Typical development
() | |
| | IL-12p70 | 2.590 (2.400; 2.750) | 2.460 (2.393; 2.568) | 0.119 | 2.520 (2.393; 2.668) | 2.475 (2.445; 2.575) | 0.757 | 2.490 (2.370; 2.600) | 2.430 (2.355; 2.475) | 0.476 | | TNF | 1.765 (1.665; 1.955) | 1.690 (1.590; 1.803) | 0.180 | 1.640 (1.550; 1.840) | 1.765 (1.580; 1.903) | 0.251 | 1.590 (1.590; 1.715) | 1.665 (1.550; 1.840) | 0.443 | | IL-10 | 0.965 (0.880; 1.130) | 1.040 (0.930; 1.100) | 0.381 | 1.090 (0.918; 1.328) | 1.040 (0.980; 1.240) | 0.638 | 1.000 (0.980; 1.455) | 0.990 (0.930; 1.090) | 0.299 | | IL-6 | 4.140 (3.860; 5.578) | 4.235 (3.983; 6.910) | 0.667 | 4.835 (3.868; 7.105) | 4.105 (3.770; 4.780) | 0.262 | 4.520 (3.780; 11.495) | 4.050 (3.505; 8.060) | 0.199 | | IL-1β | 4.380 (4.155; 5.800) | 5.790 (5.138; 7.925) | 0.012 | 5.440 (4.520; 9.090) | 7.095 (6.015; 10.045) | 0.079 | 5.190 (4.620; 7.980) | 5.985 (4.855; 8.730) | 0.527 | | CXCL8/IL-8 | 8.415 (6.370; 32.500) | 25.710 (11.213; 60.118) | 0.032 | 8.910 (7.743; 29.780) | 33.095 (15.918; 55.230) | 0.045 | 11.360 (7.820; 40.405) | 17.570 (7.628; 53.986) | 0.925 | | CXCL10/IP-10 | 2.110 (0.680; 5.320) | 4.190 (0.680; 8.980) | 0.925 | 2.310 (0.980; 13.230) | 5.26 (2.783; 10.915) | 0.396 | 1.945 (0.680; 17.430) | 4.475 (1.875; 11.950) | 0.427 | | CCL2/MCP-1 | 24.890 (23.580; 103.805) | 40.555 (10.545; 104.098) | 0.798 | 54.230 (23.333; 123.120) | 66.320 (33.910; 96.363) | 0.510 | 46.675 (20.560; 154.975) | 45.380 (20.885; 67.118) | 0.819 | | CXCL9/ MIG | 1.035 (0.733; 1.955) | 1.140 (0.780; 1.920) | 0.581 | 1.670 (1.040; 2.408) | 1.485 (1.078; 2.130) | 0.840 | 1.220 (0.660; 5.730) | 1.250 (0.785; 8.805) | 0.677 | | CCL5/RANTES | 5.920 (4.535; 7.103) | 5.590 (4.168; 6.350) | 0.600 | 5.650 (3.525; 7.628) | 4.600 (3.700; 7.660) | 0.989 | 3.635 (3.030; 4.355) | 4.74 (4.145; 6.100) | 0.020 | | BDNF | 11.271 (0.0; 36.345) | 14.081 (3.017; 17.922) | 0.600 | 54.083 (31.736; 61.840) | 24.830 (0.0; 53.813) | 0.039 | 20.226 (13.312; 27.131) | 27.131 (16.387; 36.350) | 0.112 | | GDNF | 26.023 (17.923; 62.471) | 26.927 (20.486; 56.181) | 0.798 | 58.473 (28.887; 91.789) | 117.092 (23.158; 251.53) | 0.254 | 102.304 (52.843; 430.570) | 38.340 (18.75; 64.400) | 0.005 |
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Median values (quartile 1; quartile 3). Mann–Whitney test. T1: 48 hours; T2: 72 hours; T3: 3 weeks after birth. and .
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