NLRP3 Deficiency Attenuates Renal Fibrosis and Ameliorates Mitochondrial Dysfunction in a Mouse Unilateral Ureteral Obstruction Model of Chronic Kidney Disease

Figure 3

NLRP3 deletion attenuates UUO-induced glomerular injury and tubulointerstitial fibrosis as well as deposition of collagen I and fibronectin. Glomerular injury score (a) and tubulointerstitial fibrosis index (b) are evaluated according to PAS staining and Masson staining. Semiquantitative analysis of collagen I (c) and fibronectin (d) positive areas is performed according to immunohistochemical staining. Data represent the mean ± SEM (). , WT/Sham group versus WT/UUO group; , NLRP3^−/−/UUO group versus WT/UUO group.

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