NLRP3 Deficiency Attenuates Renal Fibrosis and Ameliorates Mitochondrial Dysfunction in a Mouse Unilateral Ureteral Obstruction Model of Chronic Kidney Disease

Figure 6

NLRP3 deletion decreases UUO-upregulated expression of NLRP3 inflammasome-regulated cytokines. Expression of caspase 1, IL-1β, and IL-18 in kidney samples was detected (a). Semiquantitative analysis of caspase 1, IL-1β, and IL-18 normalized against β-actin (b). Data represent the mean ± SEM (). , compared with WT/Sham group, , NLRP3^−/−/U14 group versus WT/U14 group. U1, U3, U7, and U14 indicate that mice were sacrificed on days 1, 3, 7, and 14 after UUO.

(a)

(b)