NLRP3 Deficiency Attenuates Renal Fibrosis and Ameliorates Mitochondrial Dysfunction in a Mouse Unilateral Ureteral Obstruction Model of Chronic Kidney Disease

Figure 8

NLRP3 deletion attenuates UUO-induced mitochondrial dysfunction. Semiquantitative analysis of ATP synthase (a) and ND1 (b) normalized against 18S performed by real-time PCR. Data represent the mean ± SEM (). , compared with WT/Sham group, , NLRP3^−/−/U14 group versus WT/U14 group. U1, U3, U7, and U14 indicate that mice were sacrificed on days 1, 3, 7, and 14 after UUO.

(a)

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