Helminth Products Potently Modulate Experimental Autoimmune Encephalomyelitis by Downregulating Neuroinflammation and Promoting a Suppressive Microenvironment
TcES treatment abrogates CNS-infiltration. At the end of the experiment, mice were sacrificed to extract the lumbar region of the spinal cord and stain it with H&E to reveal inflammatory infiltration, as pinpointed by arrows in (a). The total infiltrated area of the 5 randomly selected sections per group was calculated and plotted (b), and the number of the lesions per section (c) present on every selected slide was counted to calculate mean and SEM. The data shown are representative of 2 independent experiments. Means and SEM were calculated for a group of mice. The statistical significance between groups was determined by two-tailed Student’s t-test, , , and . EAE + BSA, bovine serum albumin-treated EAE-disease mice; TcES, T. crassiceps secreted/excreted; TcES-W, TcES treatment withdrawn.
Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.