Helminth Products Potently Modulate Experimental Autoimmune Encephalomyelitis by Downregulating Neuroinflammation and Promoting a Suppressive Microenvironment
TcES treatments direct myeloid cell migration from the CNS to the peritoneal cavity. Leukocytes were obtained from the blood, spleen, CLNs, CNS, and peritoneal cavity of mice to stain CD11b+ Ly6C+ Ly6G+ (MDCs) cells. Numbers of cells (a) and frequencies (b) are shown. Cell numbers were calculated from a gate of 10000 total cells. Big and granular cells were gated to plot a big and CD11b+ gate; all data analysis was made from the latter. The data shown are representative of 2 independent experiments. Means and SEM were calculated for a group of mice. Statistical significance between groups was determined by two-tailed Student’s t-test, and .
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