Helminth Products Potently Modulate Experimental Autoimmune Encephalomyelitis by Downregulating Neuroinflammation and Promoting a Suppressive Microenvironment

Figure 9

TcES treatments direct myeloid cell migration from the CNS to the peritoneal cavity. Leukocytes were obtained from the blood, spleen, CLNs, CNS, and peritoneal cavity of mice to stain CD11b⁺ Ly6C⁺ Ly6G⁺ (MDCs) cells. Numbers of cells (a) and frequencies (b) are shown. Cell numbers were calculated from a gate of 10000 total cells. Big and granular cells were gated to plot a big and CD11b⁺ gate; all data analysis was made from the latter. The data shown are representative of 2 independent experiments. Means and SEM were calculated for a group of mice. Statistical significance between groups was determined by two-tailed Student’s t-test, and .

(a)

(b)