Helminth Products Potently Modulate Experimental Autoimmune Encephalomyelitis by Downregulating Neuroinflammation and Promoting a Suppressive Microenvironment

Table 1

TcES foster protection against EAE development.

Treatment	Resolution (%)	Average grade	Maximum grade	CDI	AUC
EAE + BSA	0%	2 ± 0.9	3.5	96	46
EAE + TcES	0%	0.6 ± 0.3	1.5	29.5	12.9

Resolution = percentage of mice in which disease resolved completely; average grade = average grade of disease of each group. Maximum grade = the peak clinical score for each group. CDI: cumulative disease index (calculated as the sum of all grades for each group); AUC: area under the curve. The data shown are representative of 4 independent experiments. Means and SEM were calculated for groups of mice. The difference between AUC and CDI were calculated by two-tailed ANOVA test and described by the following criteria: . All statistical comparisons were made against the control.