Helminth Products Potently Modulate Experimental Autoimmune Encephalomyelitis by Downregulating Neuroinflammation and Promoting a Suppressive Microenvironment

Table 2

TcES modulates EAE better than dexamethasone.

Treatment	Resolution (%)	Average grade	Maximum grade	CDI	AUC
EAE + BSA	0%	1.9 ± 1	3.5	71	32.1
EAE + TcES	0%	0.5 ± 0.4	1.5	20.5	9.5
EAE + Dex	0%	1 ± 0.6	2.5	39	18.2

Resolution = percentage of mice in which disease resolved completely; average grade = average grade of disease of each group; maximum grade = the peak clinical score for each group. CDI: cumulative disease index (calculated as the sum of all grades for each group); AUC: area under the curve. The data shown are representative of 2 independent experiments. Means and SEM were calculated for groups of mice. The difference between AUC and CDI were calculated by two-tailed ANOVA test and described by the following criteria: and . All statistical comparisons were made against the group pinpointed by a blue parenthesis.