κ-Carrageenan Enhances Lipopolysaccharide-Induced Interleukin-8 Secretion by Stimulating the Bcl10-NF-κB Pathway in HT-29 Cells and Aggravates C. freundii-Induced Inflammation in Mice

Figure 5

The impact of κ-carrageenan on weight loss and the mortality with Citrobacter freundii DBS100-stimulated inflammation. (a) Weight changes in percentage. (b) Survival ratios. κ-Carrageenan was orally administered for 1 week prior to bacterial inoculation. Infection was performed by oral gavage with 10⁹ CFU/mouse of C. freundii DBS100. After ten days, the weight and the survival rate of the animals were recorded. Repeated measures ANOVA was used to measure differences between the groups for A; differences over time for B and differences between the interaction of experiment and time for AB shown. ANOVA and LSD post hoc test were used to examine pairwise comparisons between the groups at individual time points. , compared with the blank group. , compared with the C. freundii DBS100-treated group.

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