Relationship between the Antifungal Susceptibility Profile and the Production of Virulence-Related Hydrolytic Enzymes in Brazilian Clinical Strains of Candida glabrata

Table 3

Correlation between production of five potential fungal virulence-related enzymes and minimum inhibitory concentrations of four different antifungal drugs in 91 Brazilian clinical strains of Candida glabrata.

Antifungals	Hydrolytic enzymes, P (rs)
	Aspartic protease	Esterase	Phytase	Hemolysin	Catalase
Amphotericin B	0.7409 (0.04)	0.3865 (0.09)	0.0353 (−0.22)	0.1771 (−0.14)	0.2567 (0.12)
Fluconazole	0.7230 (−0.04)	0.1493 (0.15)	0.0910 (−0.18)	0.0040 (−0.30)	0.4128 (−0.09)
Itraconazole	0.6495 (0.05)	0.4667 (0.08)	0.3749 (0.09)	0.1418 (−0.16)	0.8592 (−0.02)
Micafungin	0.0559 (−0.20)	<0.0001 (0.40)	0.3768 (−0.09)	0.0034 (−0.30)	0.0922 (−0.18)

values of 0.05 or less (in bold) were considered statistically significant.