Review Article
Autotaxin-Lysophosphatidic Acid: From Inflammation to Cancer Development
Figure 2
LPA species. LPA is derived from phospholipids with different lengths and saturations. (a) 18 carbon LPA species with an acyl group in sn-1 position and one saturation are the most potent activator of the LPA1 and LPA2 receptors [7]. (b) Acyl LPA with 18 carbons, one saturation, and the fatty acid chain in sn-2 position are the most potent activator of LPA3 and LPA6 [2, 34]. (c) An alkyl-LPA species with 16 carbons and no saturation are the most potent activator of LPA5 receptor [33].
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