N-Acetylcysteine Attenuates Diabetic Myocardial Ischemia Reperfusion Injury through Inhibiting Excessive Autophagy

<div>The effects of NAC on heart function and infract size (IS) in diabetic rats. (a) Infarct size (IS) is expressed as a percentage of the area at risk (AAR). (b) CK-MB release. Ischemia reperfusion (I/R) was achieved by 30-minute ischemia followed by 2-hour reperfusion in diabetic rats with or without NAC. Ctrl: nondiabetic control; D4w: 4-week diabetes; D4w + I/R: 4-week diabetic rats with ischemia/reperfusion; D4w + I/R + NAC: 4-week diabetic rats treated with N-acetylcysteine (NAC) and were subjected to ischemia/reperfusion. 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significance).</div>

Mediators of Inflammation

fig1

Figure 1

Figure 1: N-Acetylcysteine Attenuates Diabetic Myocardial Ischemia Reperfusion Injury through Inhibiting Excessive Autophagy 