N-Acetylcysteine Attenuates Diabetic Myocardial Ischemia Reperfusion Injury through Inhibiting Excessive Autophagy

Figure 2

Effects of NAC on plasma 15-F2t-IsoP, IL-6, and TNF-α releasing. (a) Plasma level of IL-6, (b) plasma level of TNF-α, and (c) plasma level of 15-F2t-IsoP. Ischemia reperfusion (I/R) was achieved by 30-minute ischemia followed by 2-hour reperfusion in diabetic rats with or without NAC. Ctrl: nondiabetic control; D4w: 4-week diabetes; D4w + I/R: 4-week diabetic rats with ischemia/reperfusion; D4w + I/R + NAC: 4-week diabetic rats treated with N-acetylcysteine (NAC) and were subjected to ischemia/reperfusion. Dates are expressed as mean ± SEM ( per group), .

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