N-Acetylcysteine Attenuates Diabetic Myocardial Ischemia Reperfusion Injury through Inhibiting Excessive Autophagy

<div>Effects of NAC on autophagy pathway. (a) Protein AMPK expression; (b) p-AMPK; (c) ratio of LC3 II/I; (d) protein P62 expression; (e) protein mTOR expression. Ischemia reperfusion (I/R) was achieved by 30-minute ischemia followed by 2-hour reperfusion in diabetic rats with or without NAC. Ctrl: nondiabetic control; D4w: 4-week diabetes; D4w + I/R: 4 weeks’ diabetic rats with ischemia/reperfusion; D4w + I/R + NAC: 4 weeks’ diabetic rats treated with N-acetylcysteine (NAC) and were subjected to ischemia/reperfusion. 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Mediators of Inflammation

fig4

Figure 4

Figure 4: N-Acetylcysteine Attenuates Diabetic Myocardial Ischemia Reperfusion Injury through Inhibiting Excessive Autophagy 