N-Acetylcysteine Attenuates Diabetic Myocardial Ischemia Reperfusion Injury through Inhibiting Excessive Autophagy

<div>Changes of PTEN, Akt, and eNOS after NAC treatment. (a) Protein p-PTEN expression; (b) protein p-Akt expression; (c) protein p-eNOS expression. Ischemia reperfusion (I/R) was achieved by 30-minute ischemia followed by 2-hour reperfusion in diabetic rats with or without NAC. Ctrl: nondiabetic control; D4w: 4-week diabetes; D4w + I/R: 4 weeks’ diabetic rats with ischemia/reperfusion; D4w + I/R + NAC: 4 weeks’ diabetic rats treated with N-acetylcysteine (NAC) and were subjected to ischemia/reperfusion. 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Mediators of Inflammation

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Figure 5

Figure 5: N-Acetylcysteine Attenuates Diabetic Myocardial Ischemia Reperfusion Injury through Inhibiting Excessive Autophagy 