Regular Voluntary Exercise Potentiates Interleukin-1β and Interleukin-18 Secretion by Increasing Caspase-1 Expression in Murine Macrophages

Figure 8

Effects of Ac-YVAD-cmk on the secretion of interleukin- (IL-) 1β and IL-18 from macrophages stimulated with or without lipopolysaccharide (LPS). Peritoneal-exudate macrophages were simultaneously treated with 100 ng/mL LPS and 10 μM Ac-YVAD-cmk. Concentrations of interleukin IL-1β (a) and IL-18 (b) in the cell culture supernatants were quantified by enzyme-linked immunosorbent assay (ELISA). Mean ± standard error of the mean (SEM; ) values are provided. ; (by one-way analysis of variance [ANOVA] and the Bonferroni test).

(a)

(b)