Global Autorecognition and Activation of Complement by Mannan-Binding Lectin in a Mouse Model of Type 1 Diabetes

Figure 5

Ex vivo imaging and region of interest (ROI) quantification of selected organs from diabetic and nondiabetic mice injected with either AF680-labelled rMBL or PBS. (a) Heart, (b) liver (right lobe), (c) brain, (d) spleen, (e) lung (superior left lobe), (f) part of the pancreas, (g) part of the small intestines, (h) and part of the large intestines. Left side, top: CCD photo, bottom: fluorescent image. Scale bar is given in radiant efficiency (photons/sec/cm²/sr)/(μW/cm²). Two-way ANOVA was used to test the difference between groups (P_int). Data is expressed in mean with standard deviations (SDs). Images are presented as CCD camera photo and fluorescence images. The experiment was repeated twice, and the data is based on 6 individual mice in each group ( total). Data was obtained with similar results.

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